Diphenadione

Diphenadione

Clinical data
ATC code	B01AA10 (WHO)
Identifiers
IUPAC name 2-(2,2-diphenylacetyl)-1H-indene-1,3(2H)-dione
CAS Number	82-66-6
PubChem CID	6719
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C23H16O3
Molar mass	340.371 g/mol

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List of terms related to Diphenadione

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Diphenadione is a vitamin K antagonist which has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other rodents. This chemical compound is an anti-coagulant with longer activity than warfarin and other synthetic indandione anticoagulants.

Safety and Toxicity

Diphenadione is highly toxic for human skin by all means of contact. Consumption of the drug may cause major blood clotting and irregular heartbeats. An online pesticide database gives more information about the safety of diphenadione. The U.S. Environmental Protection Agency has issued a safety handbook which explains how incidents of poisoning with similar rodenticides are usually treated. For treatment purposes Vitamin K antagonists like diphenadione are placed under the heading of coumarins and indandiones. The handbook notes that "...as agents specifically designed to kill mammals, often their toxicity is very similar for the target rodents and for humans."