Transcription factor COE1 is a protein that in humans is encoded by the EBF1gene.
EBF1 stands for Early B-Cell Factor 1.[1][2][3]
EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.[4][5] The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.[6]
↑Milatovich A, Qiu RG, Grosschedl R, Francke U (Jul 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mamm. Genome. 5 (4): 211–5. doi:10.1007/BF00360547. PMID8012110.
↑Tsai RY, Reed RR (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. PMID9151733.
Wang MM, Reed RR (1993). "Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast". Nature. 364 (6433): 121–6. doi:10.1038/364121a0. PMID8321284.
Hagman J, Belanger C, Travis A, Turck CW, Grosschedl R (1993). "Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression". Genes Dev. 7 (5): 760–73. doi:10.1101/gad.7.5.760. PMID8491377.
Tsai RY, Reed RR (1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. PMID9151733.
Gisler R, Jacobsen SE, Sigvardsson M (2000). "Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse". Blood. 96 (4): 1457–64. PMID10942392.
Gisler R, Sigvardsson M (2002). "The human V-preB promoter is a target for coordinated activation by early B cell factor and E47". J. Immunol. 168 (10): 5130–8. doi:10.4049/jimmunol.168.10.5130. PMID11994467.
Smith EM, Gisler R, Sigvardsson M (2002). "Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression". J. Immunol. 169 (1): 261–70. doi:10.4049/jimmunol.169.1.261. PMID12077253.
Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, Pucillo C (2004). "CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism". J. Biol. Chem. 279 (3): 1777–86. doi:10.1074/jbc.M305418200. PMID14594818.
Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S (2004). "Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells". Blood. 103 (6): 2062–70. doi:10.1182/blood-2003-07-2388. PMID14630787.
Smith EM, Akerblad P, Kadesch T, Axelson H, Sigvardsson M (2005). "Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development". Blood. 106 (6): 1995–2001. doi:10.1182/blood-2004-12-4744. PMID15920012.
Akerblad P, Månsson R, Lagergren A, Westerlund S, Basta B, Lind U, Thelin A, Gisler R, Liberg D, Nelander S, Bamberg K, Sigvardsson M (2005). "Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics". Physiol. Genomics. 23 (2): 206–16. doi:10.1152/physiolgenomics.00015.2005. PMID16106032.
