Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene .[1]
EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.[1] [2]
Model organisms Model organisms have been used in the study of EIF4E3 function. A conditional knockout mouse line, called Eif4e3tm1a(KOMP)Wtsi [7] [8] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute .[9] [10] [11]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5] [12] mutant mice but no significant abnormalities were observed.[5]
References
↑ 1.0 1.1 "Entrez Gene: Eukaryotic translation initiation factor 4E family member 3" . Retrieved 2011-09-28 .↑ Joshi, B.; Cameron, A.; Jagus, R. (2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry . 271 (11): 2189–2203. doi :10.1111/j.1432-1033.2004.04149.x . PMID 15153109 . ↑ "Salmonella infection data for Eif4e3" . Wellcome Trust Sanger Institute.↑ "Citrobacter infection data for Eif4e3" . Wellcome Trust Sanger Institute.↑ 5.0 5.1 5.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 (S248): 0. doi :10.1111/j.1755-3768.2010.4142.x . ↑ Mouse Resources Portal , Wellcome Trust Sanger Institute.↑ "International Knockout Mouse Consortium" .↑ "Mouse Genome Informatics" .↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–342. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature . 474 (7351): 262–3. doi :10.1038/474262a . PMID 21677718 . ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 . PMID 17218247 . ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biol . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 .
