Ectonucleoside triphosphate diphosphohydrolase 4

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Ectonucleoside triphosphate diphosphohydrolase 4 is a protein that in humans is encoded by the ENTPD4 gene.

Function

This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium ion-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011].

Further reading

• Biederbick A, Rösser R, Storre J, Elsässer HP (June 2004). "The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70". BMC Biochem. 5: 8. doi:10.1186/1471-2091-5-8. PMC 443525. PMID 15200686.
• Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL (May 2010). "Human variation in alcohol response is influenced by variation in neuronal signaling genes". Alcohol. Clin. Exp. Res. 34 (5): 800–12. doi:10.1111/j.1530-0277.2010.01152.x. PMID 20201926.
• Saito A, Fujikura-Ouchi Y, Ito C, Matsuoka H, Shimoda K, Akiyama K (January 2011). "An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia". Psychiatry Res. 185 (1–2): 9–15. doi:10.1016/j.psychres.2009.09.018. PMID 20537721.
• Saito A, Fujikura-Ouchi Y, Ito C, Matsuoka H, Shimoda K, Akiyama K (January 2011). "An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia". Psychiatry Res. 185 (1–2): 9–15. doi:10.1016/j.psychres.2009.09.018. PMID 20537721.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.