Eczema causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, DMD, MD[2]
Overview
The etiology of eczema is multifactorial and complex. This involves aberrations in genetic components, adverse effects of certain medications, and some environmental factors.
Etiology of Eczema
Genetic problem
- Damage from the enzymatic activity of allergens is usually prevented by the body's own protease inhibitors, such as LEKTI, produced from the gene SPINK5.
- Lack of filaggrin gene causes dry skin. [1]
Eczema as an Adverse Drug Reaction
- Eczema can also be brought about by some adverse effects of medications.
- Below is a list of commonly prescribed medications with eczema as the common adverse drug effect (Table 1).
| Medication |
|---|
| Cidofovir |
| Flurbiprofen |
| Olaparib |
| Siltuximab |
| Sorafenib |
| Tiagabine |
References
- ↑ Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP; et al. (2006). "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis". Nat Genet. 38 (4): 441–6. doi:10.1038/ng1767. PMID 16550169.