Endocardial cushion defect causes
Jump to navigation
Jump to search
|
Endocardial cushion defect Microchapters |
|
Differentiating Endocardial cushion defect from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Endocardial cushion defect causes On the Web |
|
American Roentgen Ray Society Images of Endocardial cushion defect causes |
|
Risk calculators and risk factors for Endocardial cushion defect causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
The most common cause of endocardial cushion defect is genetic mutations. Endocardial cushion defects are transmitted in families as an autosomal dominant. The characteristic pattern of genetic mutation has been attributed to trisomy 21 and Down syndrome.
Causes
- The most common cause of endocardial cushion defect is genetic mutations.[1]
- Endocardoal cushion defects are transmitted in families as an autosomal dominant.
- The characteristic pattern of genetic mutation has been attributed to trisomy 21 and Down syndrome. Other common causes include
- Deletion of 8p
- Partial 10q monosomy
- Partial 13q monosomy
- Alteration of growth factor beta and platelet-derived growth factor in fetus during embryogenesis leads to cardiac tissue malformation.
References
- ↑ Craig B (December 2006). "Atrioventricular septal defect: from fetus to adult". Heart. 92 (12): 1879–85. doi:10.1136/hrt.2006.093344. PMC 1861295. PMID 17105897.