Eosinophilia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

• Adrenal insufficiency
• Asthma
• Atheroembolic disease
• Atopic dermatitis
• Fungal infections
• Hypereosinophilic syndromes
• Immunodeficiency states
• Leukemia
• Lymphoma
• Mastocytosis
• Medication-related eosinophilia
• Parasitic infections
• Rhinitis syndromes
• Vasculitis

Causes by Organ System

Cardiovascular	Endomyocardial fibrosis, Cholesterol embolism, Loeffler endocarditis , Eosinophilic myocarditis
Chemical / poisoning	No underlying causes
Dermatologic	Erythema multiforme, Atopic dermatitis, Dermatitis herpetiformis, Eosinophilic fasciitis, Eosinophilic pustular folliculitis, Pemphigus vulgaris, Psoriasis, Systemic lupus erythematosus, Sarcoptes scabiei, Eczema , Exfoliative dermatitis , Urticaria , Eosinophilic panniculitis , Shulman’s syndrome , Stevens - Johnson syndrome , Duhring disease , Histiositosis with cutaneous involvement
Drug Side Effect	Aldesleukin , Allopurinol, Amikacin Sulfate , Amitriptyline, Amoxicillin, Artemether and lumefantrin, Atazanavir, Boceprevir, Capastat Sulfate , Capreomycin, Capreomycin Sulfate , Caspofungin, Cefadroxil, Cefepime, Cefotaxime Sodium , Cefpodoxime, Cefoxitin Sodium , Cefprozil, Ceftazidime , Cefuroxime, Chlorpromazine, Chlorpropamide, Clomipramine, Clozapine, Clobazam, Daptomycin, Desipramine, Dothiepin, Doxycycline, Eslicarbazepine acetate, Enfuvirtide, Ethambutol, Ethosuximide, Etravirine, Flucytosine, Gold salts, Granulocyte-macrophage colony stimulating factor, Hydralazine, Imipramine, Interleukin 2, Isoniazid, LyphocinMaolate, Micafungin, Minocycline hydrochloride, Nalidixic acid, Nitrofurantoin, Nortriptyline, Olanzapine, Olsalazine, Oxytetracycline, Omalizumab, Oxaprozin, Oxytetracycline, Pentamidine Isethionate, Pentostatin, Pergolide, Procarbazine, Sipuleucel-T, Sodium aurothiomalate, Streptomycin, Sulfasalazine Sulphonamides, Spironolactone, Tobacco smoking, Thalidomide, Thiothixene, Trimethadione, Tryptophan, Tobramycin, Vancomycin,
Ear Nose Throat	No underlying causes
Endocrine	Adrenal cortex insufficiency, Addisons disease , Adrenocortical insufficiency
Environmental	An allergic reaction to an environmental antigen
Gastroenterologic	Inflammatory Bowel Disease , Cirrhosis of liver , Chronic active hepatitis , Eosinophilic Gastroenteritis , Peritoneal dialysis
Genetic	Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 2, Familial eosinophilia, Kostmann disease, Omenn syndrome, Wiskott-Aldrich syndrome, TAR syndrome, kostmann syndrome, Chromosome 21 partial deletion
Hematologic	Acute lymphoblastic leukemia, Chronic myeloid leukaemia, Hodgkin lymphoma, Thrombocytopenia with absent radii , Familial reticuloendotheliosis with eosinophilia
Iatrogenic	Radiotherapy
Infectious Disease	Acanthocheilonemiasis, Alveolar hydatid disease, Ancylostoma caninum, Ancylostoma duodenale, Angiostrongyliasis, Anisakiasis, Ascariasis, Capillaria, Clonorchiasis, Coccidioidomycosis, Dicrocoelium dendriticum fluke, Dracunculiasis, Echinococcus granulosus, Fasciola hepatica, Gnathostomiasis, Heterophyiasis, Lepromatous leprosy, Loa loa filariasis, Lymphatic filariasis, Mansonelliasis, Metagonimiasis, Mycobacterium tuberculosis, Onchocerciasis, Opisthorchiasis, Paragonimiasis, Schistosoma haematobium, Schistosoma mansoni, Strongyloidiasis, Toxocariasis, Trichinella spiralis, Pneumocystis jirovecii infection , Visceral larva migrans , Brucellosis , Cat-scratch fever , Chlamydial pneumonia of infancy , Infectious lymphocytosis , Infectious mononucleosis , Scarlet fever, Amebiasis , Malaria
Musculoskeletal / Ortho	Polyarteritis nodosa, Polymyositis, Rheumatoid disease, Dressler's syndrome , Eosinophilic fasciitis , Idiopathic eosinophilic synovitis , Progressive systemic sclerosis (scleroderma) , SLE , Sjögren's syndrome , Sarcoidosis , Eosinophilia – Myalgia syndrome , Dermatomyositis
Neurologic	No underlying causes
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute lymphoblastic leukemia, Chronic myeloid leukaemia, Hodgkin lymphoma, Immunoblastic lymphadenopathy , Sarcomas and carcinomas of ovary, Carcinoma of pancreas , Carcinoma of lung , Carcinoma of colon, Carcinoma of cervix , Acute eosinophilic leukemia , Chronic eosinophilic leukemia , Brain tumors
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Simple pulmonary eosinophilia, Visceral larva migrans, Allergic bronchopulmonary aspergillosis, Extrinsic allergic alveolitis, Tropical pulmonary eosinophilia, Churg-Strauss syndrome, Bronchial asthma, Allergic Rhinitis, Chronic eosinophilic pneumonia , Occupational lung diseases , Idiopathic eosinophilic chronic pneumopathy , Magrassi- Leonardi syndrome
Renal / Electrolyte	Interstitial nephritis, Eosinophilic cystitis , Hemodialysis , CRF not on renal replacement therapy , Diffuse proliferative glomerular nephritis , Thrombotic thrombocytopenic purpura , Renal cell carcinoma
Rheum / Immune / Allergy	Eosinophilia-myalgia syndrome,Hyper-IgE syndrome , IgA deficiency , Wiskott-Aldrich syndrome ,Graft versus host immunologic reactions ,Milk protein allergy , Omenn syndrome , Severe congenital Neutropenia
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Angiolymphoid hyperplasia with eosinophilia, Eosinophilic cellulitis, Hypereosinophilic syndrome, Kimura disease, Familial eosinophilia , Episodic angioedema with eosinophilia , Aggressive systemic mastocytosis

Causes in Alphabetical Order

• Acanthocheilonemiasis
• Acute eosinophilic leukemia
• Acute lymphoblastic leukemia
• Acute myeloid leukemia
• Addison's disease
• Adrenocortical insufficiency
• Aggressive systemic mastocytosis
• Aldesleukin
• Alfotax
• Allergic bronchopulmonary aspergillosis
• Allergic inflammation
• Allergic rhinitis
• Allopurinol
• Alveolar hydatid disease
• Amebiasis
• Amikacin sulfate
• Amikafur
• Amikayect
• Amikin
• Amitriptyline
• Ampicillin
• Amoxicillin
• Ancylostoma caninum
• Ancylostoma duodenale
• Angiolymphoid hyperplasia with eosinophilia
• Angiostrongyliasis costaricensis
• Anisakiasis
• Anthelmintic
• Artemether and lumefantrin
• Ascariasis
• Aspergillosis
• Aspirin
• Asthma
• Atheroembolic disease
• Atopic and related diseases
• Atopic dermatitis
• Auranofin
• Autoimmune lymphoproliferative syndrome type 1
• Autoimmune lymphoproliferative syndrome type 2
• Aztreonam
• B cell non-Hodgkin lymphoma
• Baylisascaris infection
• Benaxima
• Besnier-Boeck-Schaumann disease
• Beta blockers
• Biclin
• Biosint
• Boceprevir
• Brain tumors
• Bronchial asthma
• Brucellosis
• Buerger's disease
• Capastat sulfate
• Capillaria
• Capreomycin sulfate
• Capreomycin
• Carbamazepine
• Carcinoma especially with radiation therapy
• Caspofungin
• Cat-scratch fever
• Cefaclor
• Cefadroxil
• Cefaxim
• Cefizox
• Cefoclin
• Cefotaxime sodium
• Cefoxitin sodium
• Cefprozil
• Ceftazidime
• Ceftazim
• Ceftin
• Ceftizoxime
• Cefuroxime
• Cephalosporin
• Ceptaz
• Chlamydial pneumonia of infancy
• Chlorphenesin carbamate
• Chlorpropamide
• Cholesterol embolism
• Chromosome 21 partial deletion
• Chronic eosinophilic leukemia
• Chronic active hepatitis
• Chronic eosinophilic leukemia
• Chronic eosinophilic pneumonia
• Chronic myeloid leukaemia
• Churg-Strauss syndrome
• Cirrhosis
• Claforan
• Clofibrate
• Clomipramine
• Clonorchis sinensis
• Coccidioidomycosis
• Connective tissue disease
• Cysticercosis
• Cytomegalovirus
• Dantrolene
• Dapsone
• Daptomycin
• Dermatitis herpetiformis
• Dermatomyositis
• Desipramine
• Dicrocoelium dendriticum fluke
• Dientamoeba fragilis
• Diethylcarbamazine
• Diffuse proliferative glomerular nephritis
• Dothiepin
• Doxycycline

• Dracunculiasis
• Dressler's syndrome
• Duhring's disease
• Echinococcosis
• Echinococcus granulosus
• Echinococcus
• Eczema
• Endomyocardial fibrosis
• Enfuvirtide
• Eosinophilia-myalgia syndrome
• Eosinophilic cellulitis
• Eosinophilic cystitis
• Eosinophilic fasciitis
• Eosinophilic folliculitis
• Eosinophilic gastroenteritis
• Eosinophilic granuloma
• Eosinophilic leukemia
• Eosinophilic myocarditis
• Eosinophilic panniculitis
• Eosinophilic pneumonia
• Eosinophilic pulmonary syndrome
• Eosinophilic pustular folliculitis
• Episodic angioedema with eosinophilia
• Erythema multiforme
• Ethosuximide
• Etravirine
• Exfoliative dermatitis
• Extrinsic allergic alveolitis
• Familial eosinophilia
• Familial reticuloendotheliosis with eosinophilia
• Farmer's lung
• Fasciola hepatica
• Fascioliasis
• Fasciolopsis buski
• Filariases
• Flukes
• Food allergy
• Fortaz
• Fortum
• Fotexina
• Froxal
• Fungal infections
• Gamikal
• GM-CSF
• Gnathostoma hispidum
• Gnathostoma spinigerum
• Gnathostomiasis
• Gold salts
• Graft versus host immunologic reactions
• Granulocyte-macrophage colony stimulating factor
• Helminth infections
• Hemodialysis
• Heterophyiasis
• Histiositosis with cutaneous involvement
• Hodgkin lymphoma
• Hookworm infection
• Human T-lymphotropic virus (HTLV)-I
• Human T-lymphotropic virus (HTLV)-II
• Hydralazine
• Hyper-IgE syndrome
• Hypereosinophilic syndrome
• Hypersensitivity
• Hypoadrenalism
• Idiopathic eosinophilic chronic pneumopathy
• Idiopathic eosinophilic synovitis
• IgA deficiency
• Imipramine
• Immunoblastic lymphadenopathy
• Infectious lymphocytosis
• Infectious mononucleosis
• Inflammatory Bowel Disease
• Interleukin-2
• Interstitial nephritis
• Isoniazid
• Isospora belli
• Kefurox
• Ketorolac
• Kimura disease
• Kostmann disease
• Kostmann syndrome
• L-tryptophan contaminant
• Lepromatous leprosy
• Leukemia
• Loa loa
• Loeffler endocarditis
• Loeffler's syndrome
• Lymphomas
• Lyphocin maolate
• Magrassi-Leonardi syndrome
• Malaria
• Malignancy
• Mansonella ozzardi
• Mansonelliasis
• Maolate
• Mastocytosis
• Medication-related eosinophilia
• Mefoxin
• Metagonimiasis
• Micafungin
• Milk protein allergy
• Minocycline
• Modafinil

• Mycobacterium tuberculosis
• Myeloproliferative disorders
• Nalidixic acid
• Nasal polyposis
• Nitrofurantoin
• Nonallergic rhinitis with eosinophilia syndrome (NARES)
• Nonsteroidal antiinflammatory agents
• Nortriptyline
• NSAID nephropathy
• Occupational lung diseases
• Ocular larva migrans
• Olanzapine
• Omenn syndrome
• Onchocerciasis
• Opisthorchiasis
• Oxaprozin
• Oxytetracycline
• Papaverine
• Paragonimiasis
• Paraneoplastic syndrome
• Parasitic infection
• Pemphigus vulgaris
• Penicillin
• Pentostatin
• Pergolide
• Peritoneal dialysis
• Phenytoin
• Pneumocystis jirovecii
• Polyarteritis nodosa
• Polymyositis
• Praziquantel
• Precursor B-cell acute lymphoblastic leukemia with t(5;14)
• Precursor T-cell lymphoblastic lymphoma with t(8;13)
• Primary sclerosing cholangitis
• Procarbazine
• Progressive systemic sclerosis
• Proleukin
• Psoriasis
• Pulmonary eosinophilia
• Pyrimethamine
• Radiotherapy
• Ranitidine
• Renal cell carcinoma
• Rheumatoid arthritis
• Rice millers syndrome
• River Blindness
• Sarcoidosis
• Sarcoptes scabiei
• Scabies
• Scarlet fever
• Schistosoma haematobium
• Schistosoma mansoni
• Selective serotonin reuptake inhibitor
• Shulman’s syndrome
• Simple pulmonary eosinophilia
• Sipuleucel-T
• Sjögren's syndrome
• Spirometra erinace-ieuropaei
• Spirometra mansoni
• Spirometra mansonoides
• Spirometra theileri
• Stevens-Johnson syndrome
• Strongyloidiasis
• Sulphonamides
• Systemic lupus erythematosus
• Systemic mastocytosis
• Tagal
• Taloken
• Tapeworms
• Taporin
• TAR syndrome
• Tazicef
• Tazidime
• Tetracyclines
• Thrombocytopenia with absent radii
• Thrombotic thrombocytopenic purpura
• Thymoma
• Tissue invasion by parasites
• Tobacco smoking
• Toxic oil syndrome
• Toxocara canis
• Toxocariasis
• Transplant rejection
• Trichinella spiralis
• Tropical pulmonary eosinophilia
• Tryptophan
• Urticaria
• Vancoled
• Vancomycin Hydrochloride
• Vancomycin
• Vasculitis
• Viken
• Visceral larva migrans
• Waytrax
• Wegener granulomatosis
• White blood cells
• Wiskott-Aldrich syndrome
• Wuchereria bancrofti
• Yectamid
• Zimelidine
• Zinacef