FAM114A2 (chromosome 5open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.
The FAM114A2 protein is 505 amino acids long[1] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.[2] It is predicted to stay in the nucleus after translation [3]
There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 [4]
This protein is thought to include a P loop[5] that suggests a role in ATP- and/or GTP-binding [6]
Gene
The FAM114A2 gene is located on chromosome 5 (5q31-33).[7] This gene has 14 exons spanning through its sequence.[1] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.[1] It is expressed at high levels in most tissues of the human body.[7] It is also highly expressed in tissues in the human brain [8]
↑Saraste M, Sibbald PR, Wittinghofer A (November 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID2126155.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
