FAT (gene)

FAT tumor suppressor homolog 1 (Drosophila)
Identifiers
Symbols	FAT ; CDHF7; FAT1; ME5; hFat1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 66302
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

FAT tumor suppressor homolog 1 (Drosophila), also known as FAT, is a human gene.

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.

Further reading

• Dunne J, Hanby AM, Poulsom R; et al. (1996). "Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule". Genomics. 30 (2): 207–23. PMID 8586420.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Matsuyoshi N, Tanaka T, Toda K, Imamura S (1997). "Identification of novel cadherins expressed in human melanoma cells". J. Invest. Dermatol. 108 (6): 908–13. PMID 9182820.CS1 maint: Multiple names: authors list (link)
• Matsuyoshi N, Imamura S (1997). "Multiple cadherins are expressed in human fibroblasts". Biochem. Biophys. Res. Commun. 235 (2): 355–8. doi:10.1006/bbrc.1997.6707. PMID 9199196.
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanoue T, Takeichi M (2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact". J. Cell Biol. 165 (4): 517–28. doi:10.1083/jcb.200403006. PMID 15148305.
• Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu Q (2005). "Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes". Genetics. 169 (4): 2179–88. doi:10.1534/genetics.104.037606. PMID 15744052.
• Magg T, Schreiner D, Solis GP; et al. (2005). "Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus". Exp. Cell Res. 307 (1): 100–8. doi:10.1016/j.yexcr.2005.03.006. PMID 15922730.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blair IP, Chetcuti AF, Badenhop RF; et al. (2006). "Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele". Mol. Psychiatry. 11 (4): 372–83. doi:10.1038/sj.mp.4001784. PMID 16402135.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schreiner D, Müller K, Hofer HW (2006). "The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins". FEBS Lett. 580 (22): 5295–300. doi:10.1016/j.febslet.2006.08.079. PMID 16979624.CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakaya K, Yamagata HD, Arita N; et al. (2007). "Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array". Oncogene. 26 (36): 5300–8. doi:10.1038/sj.onc.1210330. PMID 17325662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Braun GS, Kretzler M, Heider T; et al. (2007). "Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells". J. Biol. Chem. 282 (31): 22823–33. doi:10.1074/jbc.M701758200. PMID 17500054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)