FGF10 (gene)

Fibroblast growth factor 10
PDB rendering based on 1nun.
Identifiers
Symbols	FGF10 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3284
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Overview

Fibroblast growth factor 10, also known as FGF10, is a human gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.

Further reading

• Emoto H, Tagashira S, Mattei MG; et al. (1997). "Structure and expression of human fibroblast growth factor-10". J. Biol. Chem. 272 (37): 23191–4. PMID 9287324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Igarashi M, Finch PW, Aaronson SA (1998). "Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7)". J. Biol. Chem. 273 (21): 13230–5. PMID 9582367.CS1 maint: Multiple names: authors list (link)
• Sekine K, Ohuchi H, Fujiwara M; et al. (1999). "Fgf10 is essential for limb and lung formation". Nat. Genet. 21 (1): 138–41. doi:10.1038/5096. PMID 9916808.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jimenez PA, Rampy MA (1999). "Keratinocyte growth factor-2 accelerates wound healing in incisional wounds". J. Surg. Res. 81 (2): 238–42. doi:10.1006/jsre.1998.5501. PMID 9927546.
• Ropiquet F, Giri D, Kwabi-Addo B; et al. (2000). "FGF-10 is expressed at low levels in the human prostate". Prostate. 44 (4): 334–8. PMID 10951499.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marchese C, Felici A, Visco V; et al. (2001). "Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes". J. Invest. Dermatol. 116 (4): 623–8. doi:10.1046/j.0022-202x.2001.01280.x. PMID 11286634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bagai S, Rubio E, Cheng JF; et al. (2002). "Fibroblast growth factor-10 is a mitogen for urothelial cells". J. Biol. Chem. 277 (26): 23828–37. doi:10.1074/jbc.M201658200. PMID 11923311.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yeh BK, Igarashi M, Eliseenkova AV; et al. (2003). "Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2266–71. doi:10.1073/pnas.0436500100. PMID 12591959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Upadhyay D, Lecuona E, Comellas A; et al. (2003). "Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway". FEBS Lett. 545 (2–3): 173–6. PMID 12804770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Izvolsky KI, Zhong L, Wei L; et al. (2003). "Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (4): L838–46. doi:10.1152/ajplung.00081.2003. PMID 12818887.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomlinson DC, Grindley JC, Thomson AA (2004). "Regulation of Fgf10 gene expression in the prostate: identification of transforming growth factor-beta1 and promoter elements". Endocrinology. 145 (4): 1988–95. doi:10.1210/en.2003-0842. PMID 14726452.CS1 maint: Multiple names: authors list (link)
• Upadhyay D, Bundesmann M, Panduri V; et al. (2004). "Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair". Am. J. Respir. Cell Mol. Biol. 31 (1): 107–13. doi:10.1165/rcmb.2003-0064OC. PMID 14975937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Theodorou V, Boer M, Weigelt B; et al. (2005). "Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas". Oncogene. 23 (36): 6047–55. doi:10.1038/sj.onc.1207816. PMID 15208658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ibrahimi OA, Yeh BK, Eliseenkova AV; et al. (2005). "Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization". Mol. Cell. Biol. 25 (2): 671–84. doi:10.1128/MCB.25.2.671-684.2005. PMID 15632068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Entesarian M, Matsson H, Klar J; et al. (2005). "Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands". Nat. Genet. 37 (2): 125–7. doi:10.1038/ng1507. PMID 15654336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kovacs D, Falchi M, Cardinali G; et al. (2005). "Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis". Exp. Dermatol. 14 (2): 130–7. doi:10.1111/j.0906-6705.2005.00261.x. PMID 15679583.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ye F, Duvillié B, Scharfmann R (2005). "Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells". Diabetologia. 48 (2): 277–81. doi:10.1007/s00125-004-1638-6. PMID 15690149.CS1 maint: Multiple names: authors list (link)
• Beer HD, Bittner M, Niklaus G; et al. (2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair". Oncogene. 24 (34): 5269–77. doi:10.1038/sj.onc.1208560. PMID 15806171.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)