FGF3 (gene)

Fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
Identifiers
Symbols	FGF3 ; HBGF-3; INT2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3841
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog), also known as FGF3, is a human gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.

Further reading

• Represa J, León Y, Miner C, Giraldez F (1991). "The int-2 proto-oncogene is responsible for induction of the inner ear". Nature. 353 (6344): 561–3. doi:10.1038/353561a0. PMID 1922362.CS1 maint: Multiple names: authors list (link)
• Brookes S, Smith R, Casey G; et al. (1989). "Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells". Oncogene. 4 (4): 429–36. PMID 2470007.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Casey G, Smith R, McGillivray D; et al. (1987). "Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene". Mol. Cell. Biol. 6 (2): 502–10. PMID 3023852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mansour SL, Goddard JM, Capecchi MR (1993). "Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear". Development. 117 (1): 13–28. PMID 8223243.CS1 maint: Multiple names: authors list (link)
• Ornitz DM, Xu J, Colvin JS; et al. (1996). "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem. 271 (25): 15292–7. PMID 8663044.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Galdemard C, Yamagata H, Brison O, Lavialle C (2000). "Regulation of FGF-3 gene expression in tumorigenic and non-tumorigenic clones of a human colon carcinoma cell line". J. Biol. Chem. 275 (23): 17364–73. doi:10.1074/jbc.M909316199. PMID 10749884.CS1 maint: Multiple names: authors list (link)
• Reimers K, Antoine M, Zapatka M; et al. (2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMID 11438656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J. Biol. Chem. 279 (38): 40146–52. doi:10.1074/jbc.M405795200. PMID 15199049.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Antoine M, Reimers K, Wirz W; et al. (2006). "Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2". Biochem. Biophys. Res. Commun. 338 (2): 1248–55. doi:10.1016/j.bbrc.2005.10.079. PMID 16263090.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tekin M, Hişmi BO, Fitoz S; et al. (2007). "Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia". Am. J. Hum. Genet. 80 (2): 338–44. doi:10.1086/510920. PMID 17236138.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Riley BM, Mansilla MA, Ma J; et al. (2007). "Impaired FGF signaling contributes to cleft lip and palate". Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4512–7. doi:10.1073/pnas.0607956104. PMID 17360555.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)