FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPLgene.[1]
Function
FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.[2]
FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.[3] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.[4]
FKBPL has also been shown to influence estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug tamoxifen.[6]
References
↑Robson TA, Lohrer H, Bailie JR, Hirst DG, Joiner MC, Arrand JE (February 1997). "Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line". Biochem. Soc. Trans. 25 (1): 335–42. PMID9056895.
↑Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I, Jones H, McKeown SR, Hirst DG (November 1999). "A novel human stress response-related gene with a potential role in induced radioresistance". Radiat. Res. Radiation Research, Vol. 152, No. 5. 152 (5): 451–61. doi:10.2307/3580140. JSTOR3580140. PMID10521921.
↑Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A (January 2005). "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein". Mol. Cell. 17 (2): 237–49. doi:10.1016/j.molcel.2004.11.049. PMID15664193.
↑McKeen HD, McAlpine K, Valentine A, Quinn DJ, McClelland K, Byrne C, O'Rourke M, Young S, Scott CJ, McCarthy HO, Hirst DG, Robson T (July 2008). "A novel FK506-like binding protein (FKBPL) interacts with the glucocorticoid receptor and regulates steroid receptor signalling". Endocrinology. 149 (11): 5724–34. doi:10.1210/en.2008-0168. PMID18669603.
↑McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T (February 2010). "FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy". Cancer Res. 70 (3): 1090–100. doi:10.1158/0008-5472.CAN-09-2515. PMID20103631.
