FLT3LG

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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
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UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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Wikidata
View/Edit Human

Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene.

Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. For example, it is a major growth factor stimulating the growth of dendritic cells.

Further reading

• Lyman SD, James L, Vanden Bos T, et al. (1994). "Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells". Cell. 75 (6): 1157–67. doi:10.1016/0092-8674(93)90325-K. PMID 7505204.
• Lyman SD, Stocking K, Davison B, et al. (1995). "Structural analysis of human and murine flt3 ligand genomic loci". Oncogene. 11 (6): 1165–72. PMID 7566977.
• Lyman SD, James L, Escobar S, et al. (1995). "Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs". Oncogene. 10 (1): 149–57. PMID 7824267.
• Hannum C, Culpepper J, Campbell D, et al. (1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs". Nature. 368 (6472): 643–8. doi:10.1038/368643a0. PMID 8145851.
• Lyman SD, James L, Johnson L, et al. (1994). "Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells". Blood. 83 (10): 2795–801. PMID 8180375.
• Slanicka Krieger M, Nissen C, Manz CY, et al. (1998). "The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow". Exp. Hematol. 26 (5): 365–73. PMID 9590652.
• Graddis TJ, Brasel K, Friend D, et al. (1998). "Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen". J. Biol. Chem. 273 (28): 17626–33. doi:10.1074/jbc.273.28.17626. PMID 9651358.
• Solanilla A, Grosset C, Lemercier C, et al. (2000). "Expression of Flt3-ligand by the endothelial cell". Leukemia. 14 (1): 153–62. doi:10.1038/sj.leu.2401635. PMID 10637491.
• Savvides SN; Boone T; Karplus P.A. (2000). "Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots". Nat. Struct. Biol. 7 (6): 486–91. doi:10.1038/75896. PMID 10881197.
• Chklovskaia E, Nissen C, Landmann L, et al. (2001). "Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A". Blood. 97 (4): 1027–34. doi:10.1182/blood.V97.4.1027. PMID 11159533.
• Agrawal DK, Hopfenspirger MT, Chavez J, Talmadge JE (2002). "Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model". Int. Immunopharmacol. 1 (12): 2081–9. doi:10.1016/S1567-5769(01)00122-9. PMID 11710537.
• Li H, Cai Y, Xu J (2002). "[Localization of a FLT3 ligand isoform in human tissues]". Zhonghua Xue Ye Xue Za Zhi. 20 (6): 285–7. PMID 11721383.
• Feugier P, Jo DY, Shieh JH, et al. (2003). "Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand". J. Hematother. Stem Cell Res. 11 (1): 127–38. doi:10.1089/152581602753448595. PMID 11847009.
• O'Keeffe M, Hochrein H, Vremec D, et al. (2002). "Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice". Blood. 99 (6): 2122–30. doi:10.1182/blood.V99.6.2122. PMID 11877288.
• Retzlaff S, Padró T, Koch P, et al. (2002). "Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma". Oncol. Rep. 9 (3): 525–7. doi:10.3892/or.9.3.525. PMID 11956621.
• Sigurjónsson OE, Gudmundsson KO, Haraldsdóttir V, et al. (2003). "Flt3/Flk-2-ligand in synergy with thrombopoietin delays megakaryocyte development and increases the numbers of megakaryocyte progenitor cells in serum-free cultures initiated with CD34+ cells". J. Hematother. Stem Cell Res. 11 (2): 389–400. doi:10.1089/152581602753658574. PMID 11983110.
• Vávrová J, Vokurková D, Mareková M, et al. (2002). "Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells". Folia Biol. (Praha). 48 (2): 51–7. PMID 12002675.
• Testa U, Torelli GF, Riccioni R, et al. (2002). "Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors". Blood. 99 (12): 4634–7. doi:10.1182/blood.V99.12.4634. PMID 12036900.
• Mosca PJ, Hobeika AC, Colling K, et al. (2002). "Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand". J. Leukoc. Biol. 72 (3): 546–53. PMID 12223523.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.