Fatty liver natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Natural History
Complications
Up to 10% of cirrhotic alcoholic FLD will develop hepatocellular carcinoma. Overall incidence of liver cancer in non-alcoholic FLD has not been assessed yet but the association is well established.[1]
A retrospective cohort study concluded that liver failure is the main cause of morbidity and mortality in NASH-associated cirrhosis. The prognosis is either similar or less severe than HCV-cirrhosis.[2]
Prognosis
Prognosis can be determined by:
- FIB-4
- Liver stiffness measurement
- Vibration-controlled elastography (VCTE), Fibroscan
- Magnetic resonance elastography (MRE)
References
- ↑ Qian Y, Fan JG (2005). "Obesity, fatty liver and liver cancer". HBPD INT. 4 (2): 173–7. PMID 15908310.
- ↑ Hui JM, Kench JG, Chitturi S; et al. (2003). "Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C". Hepatology. 38 (2): 420–7. doi:10.1053/jhep.2003.50320. PMID 12883486.