Fibromuscular dysplasia causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohsen Basiri M.D.
Overview
The cause of fibromuscular dysplasia has not been identified.
Cause
The cause of fibromuscular dysplasia has not been identified. A variety of factors have been implicated. These include:
- Genetic predisposition with a reported autosomal mode of inheritance in some families[1][2]
- Hormonal influence, given the predominance in women of childbearing age
- Mechanical factors such as stretching of smooth muscle cells and trauma to the blood vessel wall
- Ischemia of the blood vessel wall due to fibrotic occlusion of the vasavasorum
References
- ↑ Perdu J, Boutouyrie P, Bourgain C, et al. Inheritance of arterial lesions in renal bromuscular dysplasia. J Hum Hypertens 2007; 21:393
- ↑ Ganesh SK, Morissette R, Xu Z, et al. Clinical and biochemical proles suggest bromuscular dysplasia is a systemic disease with altered TGF-β expression and connective tissue features. FASEB J 2014; 28:3313