Focal segmental glomerulosclerosis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]

Overview

Natural History, Complications, and Prognosis

Natural History

  • The symptoms of focal segmental glomerulosclerosis usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
  • The symptoms of (disease name) typically develop ___ years after exposure to ___.
  • If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

Complications

Common complications of focal segmental glomerulosclerosis include:[1]

  • End stage renal disease
  • Malnutrition
  • Infections
  • Nephrotic syndrome

Prognosis

  • There are several clinical and pathological features which predict the outcome.
  • Factors which are associated with worse prognosis of focal segmental glomerulosclerosis include:[2][3]:
    • Black race
    • Increased degrees of proteinuria
    • renal insufficiency
    • Increased severity of interstitial fibrosis
    • Tubular atrophy in biopsy specimens

References

  1. ↑ Korbet SM (1999). "Clinical picture and outcome of primary focal segmental glomerulosclerosis". Nephrol Dial Transplant. 14 Suppl 3: 68–73. PMID 10382985.
  2. ↑ "Focal Segmental Glomerulosclerosis in Nephrotic Adults: Presentation, Prognosis, and Response to Therapy of the Histologic Variants".
  3. ↑ Sohal, DS; Prabhakar, SS (November 02, 2011). "Focal segmental glomerulosclerosis" (PDF). Interchopen. InTech. Retrieved 3 December 2013. Check date values in: |date= (help)


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