Fucosyltransferase 4

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Fucosyltransferase 4 is a protein that in humans is encoded by the FUT4 gene.

Function

The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009].

Further reading

• Barry SM, Zisoulis DG, Neal JW, Clipstone NA, Kansas GS (September 2003). "Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells". Blood. 102 (5): 1771–8. doi:10.1182/blood-2002-11-3551. PMID 12738675.
• Azuma Y, Ito M, Taniguchi A, Matsumoto K (June 2004). "Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis". Biochim. Biophys. Acta. 1672 (3): 157–63. doi:10.1016/j.bbagen.2004.03.006. PMID 15182935.
• Martinez M, Joffraud M, Giraud S, Baïsse B, Bernimoulin MP, Schapira M, Spertini O (February 2005). "Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII". J. Biol. Chem. 280 (7): 5378–90. doi:10.1074/jbc.M410899200. PMID 15579466.
• Higai K, Ichikawa A, Matsumoto K (September 2006). "Binding of sialyl Lewis X antigen to lectin-like receptors on NK cells induces cytotoxicity and tyrosine phosphorylation of a 17-kDa protein". Biochim. Biophys. Acta. 1760 (9): 1355–63. doi:10.1016/j.bbagen.2006.03.015. PMID 16842926.
• Azuma Y, Kurusu Y, Sato H, Higai K, Matsumoto K (April 2007). "Increased expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis". Biol. Pharm. Bull. 30 (4): 655–60. PMID 17409497.
• Yang X, Zhang Z, Jia S, Liu Y, Wang X, Yan Q (2007). "Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation". Int. J. Biochem. Cell Biol. 39 (9): 1722–30. doi:10.1016/j.biocel.2007.04.024. PMID 17556010.
• Cruse JM, Lewis RE, Sanders CM, Webb RN, Beason KL, Lam J, Koehler J (October 2007). "Diminished CD10, CD13, and CD15 expression in a differentiated granulocyte population in CML". Exp. Mol. Pathol. 83 (2): 274–6. doi:10.1016/j.yexmp.2007.05.005. PMID 17662271.
• Zhang Z, Sun P, Liu J, Fu L, Yan J, Liu Y, Yu L, Wang X, Yan Q (February 2008). "Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth". Biochim. Biophys. Acta. 1783 (2): 287–96. doi:10.1016/j.bbamcr.2007.10.007. PMID 18023290.
• Plesa C, Chelghoum Y, Plesa A, Elhamri M, Tigaud I, Michallet M, Dumontet C, Thomas X (February 2008). "Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia: a single-institution experience". Cancer. 112 (3): 572–80. doi:10.1002/cncr.23219. PMID 18085638.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.