Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GBGT1gene.[1][2][3]
This gene encodes a member of the histo-blood group ABO gene family that encodes glycosyltransferases with related but distinct substrate specificity. This protein plays a role in synthesizing Forssman glycolipid (FG), a member of the globoseries glycolipid family. Human cells do not normally produce FG but produce the precursor glycolipids globotriaosylceramide and globoside. This protein may be involved in the tropism and binding of pathogenic organisms.[3]
References
↑Xu H, Storch T, Yu M, Elliott SP, Haslam DB (Nov 1999). "Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions". J Biol Chem. 274 (41): 29390–8. doi:10.1074/jbc.274.41.29390. PMID10506200.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID12107410.
