GJA7

Gap junction protein, alpha 7, 45kDa
Identifiers
Symbols	GJA7 ; CX45; DKFZp686P0738
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4016
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Gap junction protein, alpha 7, 45kDa, also known as GJA7, is a human gene.

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.

Further reading

• Kanter HL, Saffitz JE, Beyer EC (1994). "Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45". J. Mol. Cell. Cardiol. 26 (7): 861–8. doi:10.1006/jmcc.1994.1103. PMID 7966354.CS1 maint: Multiple names: authors list (link)
• Kilarski WM, Dupont E, Coppen S; et al. (1998). "Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term". Eur. J. Cell Biol. 75 (1): 1–8. PMID 9523149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vozzi C, Dupont E, Coppen SR; et al. (1999). "Chamber-related differences in connexin expression in the human heart". J. Mol. Cell. Cardiol. 31 (5): 991–1003. doi:10.1006/jmcc.1999.0937. PMID 10336839.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chanson M, Scerri I, Suter S (1999). "Defective regulation of gap junctional coupling in cystic fibrosis pancreatic duct cells". J. Clin. Invest. 103 (12): 1677–84. PMID 10377174.CS1 maint: Multiple names: authors list (link)
• Kausalya PJ, Reichert M, Hunziker W (2001). "Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells". FEBS Lett. 505 (1): 92–6. PMID 11557048.CS1 maint: Multiple names: authors list (link)
• Laing JG, Manley-Markowski RN, Koval M; et al. (2003). "Connexin45 interacts with zonula occludens-1 in osteoblastic cells". Cell Commun. Adhes. 8 (4–6): 209–12. PMID 12064590.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaba RA, Coppen SR, Dupont E; et al. (2003). "Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts". Cell Commun. Adhes. 8 (4–6): 339–43. PMID 12064615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiang Q, Fan SQ, Li J; et al. (2003). "[Expression of connexin43 and connexin45 in nasopharyngeal carcinoma]". Ai Zheng. 21 (6): 593–6. PMID 12452056.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsai MY, Lan KC, Huang KE; et al. (2004). "Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles". Fertil. Steril. 80 (6): 1437–43. PMID 14667880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valiunas V, Doronin S, Valiuniene L; et al. (2004). "Human mesenchymal stem cells make cardiac connexins and form functional gap junctions". J. Physiol. (Lond.). 555 (Pt 3): 617–26. doi:10.1113/jphysiol.2003.058719. PMID 14766937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laing JG, Koval M, Steinberg TH (2007). "Association with ZO-1 correlates with plasma membrane partitioning in truncated connexin45 mutants". J. Membr. Biol. 207 (1): 45–53. doi:10.1007/s00232-005-0803-2. PMID 16463142.CS1 maint: Multiple names: authors list (link)
• Rackauskas M, Kreuzberg MM, Pranevicius M; et al. (2007). "Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45". Biophys. J. 92 (6): 1952–65. doi:10.1529/biophysj.106.099358. PMID 17189315.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kotsias BA, Salim M, Peracchia LL, Peracchia C (2007). "Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes". J. Membr. Biol. 214 (1): 1–8. doi:10.1007/s00232-006-0064-8. PMID 17546509.CS1 maint: Multiple names: authors list (link)