GPC1 (gene)

Glypican 1
Identifiers
Symbols	GPC1 ; FLJ38078; glypican
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20477
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glypican 1, also known as GPC1, is a human gene.

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

Further reading

• Karthikeyan L, Maurel P, Rauch U; et al. (1992). "Cloning of a major heparan sulfate proteoglycan from brain and identification as the rat form of glypican". Biochem. Biophys. Res. Commun. 188 (1): 395–401. PMID 1417860.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• David G, Lories V, Decock B; et al. (1991). "Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts". J. Cell Biol. 111 (6 Pt 2): 3165–76. PMID 2148568.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vermeesch JR, Mertens G, David G, Marynen P (1995). "Assignment of the human glypican gene (GPC1) to 2q35-q37 by fluorescence in situ hybridization". Genomics. 25 (1): 327–9. PMID 7774946.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleeff J, Ishiwata T, Kumbasar A; et al. (1998). "The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer". J. Clin. Invest. 102 (9): 1662–73. PMID 9802880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gengrinovitch S, Berman B, David G; et al. (1999). "Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165". J. Biol. Chem. 274 (16): 10816–22. PMID 10196157.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liang Y, Annan RS, Carr SA; et al. (1999). "Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain". J. Biol. Chem. 274 (25): 17885–92. PMID 10364234.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schofield KP, Gallagher JT, David G (2000). "Expression of proteoglycan core proteins in human bone marrow stroma". Biochem. J. 343 Pt 3: 663–8. PMID 10527946.CS1 maint: Multiple names: authors list (link)
• Karumanchi SA, Jha V, Ramchandran R; et al. (2001). "Cell surface glypicans are low-affinity endostatin receptors". Mol. Cell. 7 (4): 811–22. PMID 11336704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ronca F, Andersen JS, Paech V, Margolis RU (2001). "Characterization of Slit protein interactions with glypican-1". J. Biol. Chem. 276 (31): 29141–7. doi:10.1074/jbc.M100240200. PMID 11375980.CS1 maint: Multiple names: authors list (link)
• Matsuda K, Maruyama H, Guo F; et al. (2001). "Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells". Cancer Res. 61 (14): 5562–9. PMID 11454708.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alvarez K, Fadic R, Brandan E (2002). "Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy". J. Cell. Biochem. 85 (4): 703–13. doi:10.1002/jcb.10184. PMID 11968010.CS1 maint: Multiple names: authors list (link)
• Ding K, Mani K, Cheng F; et al. (2002). "Copper-dependent autocleavage of glypican-1 heparan sulfate by nitric oxide derived from intrinsic nitrosothiols". J. Biol. Chem. 277 (36): 33353–60. doi:10.1074/jbc.M203383200. PMID 12084716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Belting M, Mani K, Jönsson M; et al. (2004). "Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide". J. Biol. Chem. 278 (47): 47181–9. doi:10.1074/jbc.M308325200. PMID 12972423.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watanabe N, Araki W, Chui DH; et al. (2004). "Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease". FASEB J. 18 (9): 1013–5. doi:10.1096/fj.03-1040fje. PMID 15084524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Kleeff J, Kayed H; et al. (2004). "Glypican-1 antisense transfection modulates TGF-beta-dependent signaling in Colo-357 pancreatic cancer cells". Biochem. Biophys. Res. Commun. 320 (4): 1148–55. doi:10.1016/j.bbrc.2004.06.063. PMID 15249209.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davies EJ, Blackhall FH, Shanks JH; et al. (2005). "Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer". Clin. Cancer Res. 10 (15): 5178–86. doi:10.1158/1078-0432.CCR-03-0103. PMID 15297422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)