GPC4

Glypican 4
Identifiers
Symbols	GPC4 ; K-glypican
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55582
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glypican 4, also known as GPC4, is a human gene.

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.

Further reading

• Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sheu TJ, Schwarz EM, O'Keefe RJ; et al. (2002). "Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae". J. Bone Miner. Res. 17 (5): 915–22. PMID 12009023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karumanchi SA, Jha V, Ramchandran R; et al. (2001). "Cell surface glypicans are low-affinity endostatin receptors". Mol. Cell. 7 (4): 811–22. PMID 11336704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hagihara K, Watanabe K, Chun J, Yamaguchi Y (2000). "Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells". Dev. Dyn. 219 (3): 353–67. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1059>3.0.CO;2-#. PMID 11066092.CS1 maint: Multiple names: authors list (link)
• Veugelers M, Cat BD, Muyldermans SY; et al. (2000). "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene". Hum. Mol. Genet. 9 (9): 1321–8. PMID 10814714.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Siebertz B, Stöcker G, Drzeniek Z; et al. (2000). "Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells". Biochem. J. 344 Pt 3: 937–43. PMID 10585884.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huber R, Mazzarella R, Chen CN; et al. (1999). "Glypican 3 and glypican 4 are juxtaposed in Xq26.1". Gene. 225 (1–2): 9–16. PMID 9931407.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Veugelers M, Vermeesch J, Watanabe K; et al. (1998). "GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome". Genomics. 53 (1): 1–11. doi:10.1006/geno.1998.5465. PMID 9787072.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watanabe K, Yamada H, Yamaguchi Y (1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney". J. Cell Biol. 130 (5): 1207–18. PMID 7657705.CS1 maint: Multiple names: authors list (link)