G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1gene.[1][2][3]
G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM][3]
References
↑Pizzinat N, Takesono A, Lanier SM (May 2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains". J Biol Chem. 276 (20): 16601–10. doi:10.1074/jbc.M007573200. PMID11278352.
↑Peterson YK, Bernard ML, Ma H, Hazard S III, Graber SG, Lanier SM (Nov 2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3". J Biol Chem. 275 (43): 33193–6. doi:10.1074/jbc.C000509200. PMID10969064.
Natochin M, Lester B, Peterson YK, et al. (2001). "AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin". J. Biol. Chem. 275 (52): 40981–5. doi:10.1074/jbc.M006478200. PMID11024022.
Pattingre S, De Vries L, Bauvy C, et al. (2003). "The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells". J. Biol. Chem. 278 (23): 20995–1002. doi:10.1074/jbc.M300917200. PMID12642577.
Adhikari A, Sprang SR (2004). "Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1". J. Biol. Chem. 278 (51): 51825–32. doi:10.1074/jbc.M306300200. PMID14530282.
Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell. 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID15537540.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID16458856.
