GUCA1A

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Guanylyl cyclase-activating protein 1 is an enzyme that in humans is encoded by the GUCA1A gene.

Further reading

• Subbaraya I, Ruiz CC, Helekar BS, et al. (1995). "Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene". J. Biol. Chem. 269 (49): 31080–9. PMID 7983048.
• Surguchov A, Bronson JD, Banerjee P, et al. (1997). "The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1)". Genomics. 39 (3): 312–22. doi:10.1006/geno.1996.4513. PMID 9119368.
• Dizhoor AM, Boikov SG, Olshevskaya EV (1998). "Constitutive activation of photoreceptor guanylate cyclase by Y99C mutant of GCAP-1. Possible role in causing human autosomal dominant cone degeneration". J. Biol. Chem. 273 (28): 17311–4. doi:10.1074/jbc.273.28.17311. PMID 9651312.
• Sokal I, Li N, Surgucheva I, et al. (1998). "GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy". Mol. Cell. 2 (1): 129–33. doi:10.1016/S1097-2765(00)80121-5. PMID 9702199.
• Sokal I, Li N, Verlinde CL, et al. (2001). "Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1)". Biochim. Biophys. Acta. 1498 (2–3): 233–51. doi:10.1016/S0167-4889(00)00099-9. PMID 11108966.
• Downes SM, Holder GE, Fitzke FW, et al. (2001). "Autosomal dominant cone and cone-rod dystrophy with mutations in the guanylate cyclase activator 1A gene-encoding guanylate cyclase activating protein-1". Arch. Ophthalmol. 119 (1): 96–105. doi:10.1001/archopht.119.11.1667. PMID 11146732.
• Wilkie SE, Li Y, Deery EC, et al. (2001). "Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy". Am. J. Hum. Genet. 69 (3): 471–80. doi:10.1086/323265. PMC 1235478. PMID 11484154.
• Hwang JY, Koch KW (2002). "Calcium- and myristoyl-dependent properties of guanylate cyclase-activating protein-1 and protein-2". Biochemistry. 41 (43): 13021–8. doi:10.1021/bi026618y. PMID 12390029.
• Hwang JY, Koch KW (2002). "The myristoylation of the neuronal Ca2+ -sensors guanylate cyclase-activating protein 1 and 2". Biochim. Biophys. Acta. 1600 (1–2): 111–7. doi:10.1016/S1570-9639(02)00451-X. PMID 12445466.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Pennesi ME, Howes KA, Baehr W, Wu SM (2003). "Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice". Proc. Natl. Acad. Sci. U.S.A. 100 (11): 6783–8. doi:10.1073/pnas.1130102100. PMC 164524. PMID 12732716.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Peshenko IV, Moiseyev GP, Olshevskaya EV, Dizhoor AM (2004). "Factors that determine Ca2+ sensitivity of photoreceptor guanylyl cyclase. Kinetic analysis of the interaction between the Ca2+-bound and the Ca2+-free guanylyl cyclase activating proteins (GCAPs) and recombinant photoreceptor guanylyl cyclase 1 (RetGC-1)". Biochemistry. 43 (43): 13796–804. doi:10.1021/bi048943m. PMID 15504042.
• Nishiguchi KM, Sokal I, Yang L, et al. (2004). "A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration". Invest. Ophthalmol. Vis. Sci. 45 (11): 3863–70. doi:10.1167/iovs.04-0590. PMC 1475955. PMID 15505030.
• Jiang L, Katz BJ, Yang Z, et al. (2005). "Autosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A)". Mol. Vis. 11: 143–51. PMID 15735604.
• Sokal I, Dupps WJ, Grassi MA, et al. (2005). "A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)". Invest. Ophthalmol. Vis. Sci. 46 (4): 1124–32. doi:10.1167/iovs.04-1431. PMC 1352313. PMID 15790869.
• Michaelides M, Wilkie SE, Jenkins S, et al. (2005). "Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy". Ophthalmology. 112 (8): 1442–7. doi:10.1016/j.ophtha.2005.02.024. PMID 15953638.