G protein nucleolar 3 like is a protein that in humans is encoded by the GNL3L gene.[1]
Function
The protein encoded by this gene appears to be a nucleolarGTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.
Rao MR, Kumari G, Balasundaram D, Sankaranarayanan R, Mahalingam S (2006). "A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L". J. Mol. Biol. 364 (4): 637–54. doi:10.1016/j.jmb.2006.09.007. PMID17034816.
Oktar PA, Yildirim S, Balci D, Can A (2011). "Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker". Stem Cell Rev. 7 (2): 413–24. doi:10.1007/s12015-010-9201-y. PMID21063916.
Lin T, Meng L, Lin TC, Wu LJ, Pederson T, Tsai RY (2014). "Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively". J. Cell Sci. 127 (Pt 10): 2302–12. doi:10.1242/jcs.143842. PMID24610951.
