Graft-versus-host disease risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
The most potent risk factor for GvHD is disparity in HLA alleles between the recipient and donor. Some risk factors depend on demographics of the recipient and donor.
Risk Factors
Risk factors for GvHD include:
- High degree of HLA disparity between host and donor cells[1]
- Use of unrelated donors as the stem cell source[1]
- Total body irradiation as the conditioning regimen prior to transplant[1]
- Prior acute GvHD[2]
- Use of peripheral blood stem cells[2]
- Use of a T cell replete graft[2]
- Viral infection, since this can contribute to immune activation[2]
- Male host[2]
- Multiparous female donor[2]
Protective factors include:
- High degree of HLA concordance between the host and donor
- Use of umbilical cord blood as the donor source (given decreased number of donor T cells)
References
- ↑ 1.0 1.1 1.2 Rezvani AR, Storb RF (2012). "Prevention of graft-vs.-host disease". Expert Opin Pharmacother. 13 (12): 1737–50. doi:10.1517/14656566.2012.703652. PMC 3509175. PMID 22770714.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Socié G, Ritz J (2014). "Current issues in chronic graft-versus-host disease". Blood. 124 (3): 374–84. doi:10.1182/blood-2014-01-514752. PMC 4102710. PMID 24914139.