Growth hormone deficiency diagnostic criteria
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The diagnosis of growth hormone deficiency is based on the direct hormonal criteria, indirect hormonal criteria and radiological evidence of response to GH treatment.
Diagnostic Criteria
- Diagnosis of growth hormone deficiency is a subject of debate due to high costs and complexity of investigations.
- Several types of evidence are used to diagnose GH deficiency:
- Body measurements. GH deficiency accounts for only a minority of short stature among children.
- Indirect hormonal criteria (IGF levels)
- Direct hormonal criteria (secretory patterns of GH levels or responses to GH stimulation tests)
- Response to GH treatment
- Radiological evidence of pituitary dysfunction
- Many children and adults may not meet all the diagnostic criteria.
- An ideal diagnostic test cleanly separates people who would benefit from a treatment from those who would not.