Guillain-Barré syndrome natural history, complications, and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Fahimeh Shojaei, M.D.
Overview
The symptoms of Guillain Barre syndrome typically develop 1 to 3 weeks after the Antecedent Infection. If left untreated, 65% of patients with Guillain Barre syndrome will recover with no permanent disability. 35% of them will not fully recover. 8% of these 35% will die from complication and others will have permanent disabilities.
Common complications of GBS include: respiratory failure, autonomic failure, bulbar pulsy, Deep vein thrombosis, Cardiac arrhythmia, Pain, Urinary retention, Ileus and persistent fatigue
Natural History, Complications, and Prognosis
Natural history
- The symptoms of Guillain Barre syndrome typically develop 1 to 3 weeks after the Antecedent Infection.
- If left untreated, 65% of patients with Guillain Barre syndrome will recover with no permanent disability.
- 35% of them will not fully recover. 8% of these 35% will die from complication and others will have permanent disabilities.
- Treatment will just reduce the recovery period and has no effect on natural history of the disease.
- The first symptoms are lower extremities weakness and paresthesia.[1][2][3]
Complications
- Common complications of GBS include:[4][5]
- respiratory failure
- Autonomic failure
- Bulbar pulsy
- Deep vein thrombosis
- Cardiac arrhythmia
- Pain
- Urinary retention
- Ileus
- Persistent fatigue
Prognosis
- About 65% of patients with GBS will fully recover with no permanent disability.
- 35% of them do not fully recover. 8% of this group will die from GBS complication and others will have permanent disabilities.
- Treatment of GBS just reduce the recovery time and doesn’t affect prognosis.[6]
- Overally, older patients will have worst prognosis in comparison to children who discover very fast.[1][2]
References
- ↑ 1.0 1.1 Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, Swan AV (November 1998). "Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group". Ann. Neurol. 44 (5): 780–8. doi:10.1002/ana.410440512. PMID 9818934.
- ↑ 2.0 2.1 Bradshaw DY, Jones HR (April 1992). "Guillain-Barré syndrome in children: clinical course, electrodiagnosis, and prognosis". Muscle Nerve. 15 (4): 500–6. doi:10.1002/mus.880150415. PMID 1565119.
- ↑ Mattle, Heinrich (2017). Fundamentals of neurology : an illustrated guide. Stuttgart New York: Thieme. ISBN 9783131364524.
- ↑ Dornonville de la Cour C, Jakobsen J (January 2005). "Residual neuropathy in long-term population-based follow-up of Guillain-Barré syndrome". Neurology. 64 (2): 246–53. doi:10.1212/01.WNL.0000149521.65474.83. PMID 15668421.
- ↑ Meythaler JM (August 1997). "Rehabilitation of Guillain-Barré syndrome". Arch Phys Med Rehabil. 78 (8): 872–9. PMID 9344309.
- ↑ Rees JH, Thompson RD, Smeeton NC, Hughes RA (January 1998). "Epidemiological study of Guillain-Barré syndrome in south east England". J. Neurol. Neurosurg. Psychiatry. 64 (1): 74–7. PMC 2169900. PMID 9436731.