Histone H1oo is a protein that in humans is encoded by the H1FOOgene.[1][2]
Function
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.[2]
↑Mizusawa Y, Kuji N, Tanaka Y, et al. (March 2010). "Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization". Fertil Steril. 93 (4): 1134–1141. doi:10.1016/j.fertnstert.2008.11.028. PMID19147139.
Further reading
Teranishi T, Tanaka M, Kimoto S, et al. (2004). "Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer". Dev. Biol. 266 (1): 76–86. doi:10.1016/j.ydbio.2003.10.004. PMID14729479.
Tanaka Y, Kato S, Tanaka M, et al. (2003). "Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte". Biochem. Biophys. Res. Commun. 304 (2): 351–7. doi:10.1016/S0006-291X(03)00610-7. PMID12711322.
Tanaka M, Kihara M, Hennebold JD, et al. (2005). "H1FOO is coupled to the initiation of oocytic growth". Biol. Reprod. 72 (1): 135–42. doi:10.1095/biolreprod.104.032474. PMID15371275.
Gao S, Chung YG, Parseghian MH, et al. (2004). "Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice". Dev. Biol. 266 (1): 62–75. doi:10.1016/j.ydbio.2003.10.003. PMID14729478.
