HIV Immune Complex Kidney Disease pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2];Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
Pathogenesis
Associated Conditions
The following are conditions that are associated with HIV Immune Complex Kidney Disease:
Gross Pathology
Microscopic Pathology
| Light Microscopy[1] | Electron Microscopy[2] | Immunofluorescence[3] |
| variable mesangial hypercellular endocapillaries are seen in either a focal or diffuse pattern. At times, it may also have a membranous pattern that has a distinctive spike and pinpoint-hole characteristic on the glomerular basement membrane. | variable deposits are seen within the mesangium, subendothelium, and subepithelium. Tubuloreticular aggregates may also be seen within the endothelial cells. However, not all patients display tubuloreticular aggregates, as the pattern is not seen in patients who express low viral loads(due to treatment with combined antiretroviral therapy). | IgG, IgA, IgM, C3 and C1q granules (Full-house description) is seen within the mesangium and the capillary loops. [4] |
References
- ↑ Fogo AB, Lusco MA, Najafian B, Alpers CE (2016). "AJKD Atlas of Renal Pathology: HIV-Associated Immune Complex Kidney Disease (HIVICK)". Am J Kidney Dis. 68 (2): e9–e10. doi:10.1053/j.ajkd.2016.06.003. PMID 27477364.
- ↑ Fogo AB, Lusco MA, Najafian B, Alpers CE (2016). "AJKD Atlas of Renal Pathology: HIV-Associated Immune Complex Kidney Disease (HIVICK)". Am J Kidney Dis. 68 (2): e9–e10. doi:10.1053/j.ajkd.2016.06.003. PMID 27477364.
- ↑ Fogo AB, Lusco MA, Najafian B, Alpers CE (2016). "AJKD Atlas of Renal Pathology: HIV-Associated Immune Complex Kidney Disease (HIVICK)". Am J Kidney Dis. 68 (2): e9–e10. doi:10.1053/j.ajkd.2016.06.003. PMID 27477364.
- ↑ Gerntholtz TE, Goetsch SJ, Katz I (2006). "HIV-related nephropathy: a South African perspective". Kidney Int. 69 (10): 1885–91. doi:10.1038/sj.ki.5000351. PMID 16625149.