HLA-B53
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major histocompatibility complex (human), class I, B53
| ||
| Alleles | B*5301 B*5302 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*5301 | |
| EBI-HLA | B*5302 | |
| Locus | chr.6 6p21.31 | |
HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products.[1] The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion.[2] This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. ((For terminology help see: HLA-serotype tutorial)
Serotype
| B*53 | B53 | B35 | Sample |
| allele | % | % | size (N) |
| 5301 | 86 | 5 | 3054 |
| 5302 | 80 | 20 | 5 |
B*5301 allele frequencies
| freq | ||
| ref. | Population | (%) |
| [4] | Akan Adiopodoume (Ivory Coast) | 22.7 |
| [4] | Rimaibe (Burkina Faso) | 22.3 |
| [4] | Mossi (Burkina Faso) | 20.8 |
| [4] | Bandiagara (Mali) | 15.9 |
| [4] | Sawa (Cameroon) | 11.5 |
| [4] | Lusaka (Zambia) | 10.2 |
| [4] | Baka Pygmy (Cameroon) | 10.0 |
| [4] | Guinea Bissau | 10.0 |
| [4] | Harare Shona (Zimbabwe) | 9.3 |
| [4] | Baloch (Iran) | 9.1 |
| [4] | Kenya | 8.7 |
| [4] | Canoncito Navajo (USA) | 8.5 |
| [4] | Brahui (Pakistan) | 7.7 |
| [4] | Niokholo Mandenka (Senegal) | 5.3 |
| [4] | Croatia (2) | 5.0 |
| [4] | Mongolia Khoton Tarialan | 4.9 |
| [4] | Pakistan Baloch | 4.6 |
| [4] | Casablanca (Morocco) | 3.7 |
| [4] | Arratia Basque (Spain) | 3.3 |
| [4] | Crete (Greece) | 3.2 |
| [4] | Israel Arab Druse | 2.5 |
| [4] | Israel Gaza Palestinians | 2.4 |
| [4] | Amman (Jordan ) | 2.4 |
| [4] | Tunis (Tunisia ) | 2.3 |
| [4] | Tuva (2) (Russia) | 2.2 |
| [4] | Oman | 2.1 |
| [4] | France South East | 1.6 |
| [4] | Saudi Arabia Guraiat and Hail | 1.5 |
| [4] | Berber (Morocco) | 1.4 |
| [4] | Georgia Svaneti Svans | 1.3 |
| [4] | Mongolia Khalkh Ulaanbaatar | 1.2 |
| [4] | Spain Catalonia Girona | 1.1 |
| [4] | India Andhra Pradesh Golla | 1.0 |
| [4] | Mongolia Khalha | 1.0 |
Haplotype frequencies
| freq | ||
| ref. | Population | (%) |
| Zimbabwe | 3.6 | |
| [4] | Zambia Lusaka | 2.3 |
| N. Afr. Negroid | 2.1 | |
| [4] | Kenya Luo | 1.9 |
| [4] | Cameroon Yaounde | 1.7 |
| [5] | African American | 1.5 |
| [4] | Kenya Nandi | 1.3 |
| [5] | American Hispanic | 0.2 |
| ' | ||
| A*6802 : Cw*0401 : B*5301 | ||
| [4] | Mali Bandihagara | 2.7 |
| [5] | African American | 1.4 |
| [4] | Kenya Nandi | 1.0 |
| [5] | Hispanic American | 0.6 |
| [5] | Caucasian American | 0.2 |
Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in african americans.
References
- ↑ Marsh SG, Albert ED, Bodmer WF; et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
- ↑ Allsopp CE, Hill AV, Kwiatkowski D; et al. (1991). "Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35". Hum. Immunol. 30 (2): 105–9. PMID 2022493.
- ↑ derived from IMGT/HLA
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 4.23 4.24 4.25 4.26 4.27 4.28 4.29 4.30 4.31 4.32 4.33 4.34 4.35 4.36 4.37 4.38 4.39 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in
|title=(help) - ↑ 5.0 5.1 5.2 5.3 5.4 Maiers M, Gragert L, Klitz W (2007). "High-resolution HLA alleles and haplotypes in the United States population". Hum. Immunol. 68 (9): 779–88. doi:10.1016/j.humimm.2007.04.005. PMID 17869653.