HULC (gene)

In molecular biology, Highly Up-regulated in Liver Cancer (non-protein coding), also known as HULC, is a long non-coding RNA. It was first identified in hepatocellular carcinoma, and is also expressed in colorectal carcinomas that metastasise to the liver.^[1]^[2] It may have a role in the post-transcriptional regulation of gene expression.^[1] It downregulates the expression of several microRNAs, including miR-372.^[3] Expression of HULC is upregulated by CREB, there is a CREB-binding site in the promoter of HULC. miR-372 represses translation of the kinase PRKACB, so downregulation of miR-372 leads to increased levels of PRKACB. PRKACB activates CREB by phosphorylation, therefore leading to increased expression of HULC.^[3]

References

↑ ^1.0 ^1.1 Panzitt K, Tschernatsch MM, Guelly C, Moustafa T, Stradner M, Strohmaier HM, Buck CR, Denk H, Schroeder R, Trauner M, Zatloukal K (Jan 2007). "Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA". Gastroenterology. 132 (1): 330–42. doi:10.1053/j.gastro.2006.08.026. PMID 17241883.
↑ Matouk IJ, Abbasi I, Hochberg A, Galun E, Dweik H, Akkawi M (Jun 2009). "Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis". European Journal of Gastroenterology & Hepatology. 21 (6): 688–92. doi:10.1097/meg.0b013e328306a3a2. PMID 19445043.
↑ ^3.0 ^3.1 Wang J, Liu X, Wu H, Ni P, Gu Z, Qiao Y, Chen N, Sun F, Fan Q (Sep 2010). "CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer". Nucleic Acids Research. 38 (16): 5366–83. doi:10.1093/nar/gkq285. PMC 2938198. PMID 20423907.