Hamman-Rich syndrome natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]

Overview

If left untreated, patients with acute interstitial pneumonitis have high fatality rate and die because of severe respiratory failure. Most of the survivors after initial hospitalization may develop recurrent disease or chronic lung fibrosis. Acute interstitial pneumonitis usually has a very poor prognosis.

Acute interstitial pneumonitis has an acute and severe onset, progresses very rapidly and have a high mortality rate. If left untreated, patients die because of respiratory failure. Survivors after initial hospitalization may develop recurrent disease or chronic lung fibrosis.^[1]

Prognosis of acute interstitial pneumonitis is poor.^[3]^[4]
Most patients die because of acute respiratory failure or its complications.
Mortality rate is very high, more than half of the patients die within 2 months. Patients who survive the initial hospitalization die within six months of presentation of disease.
Recurrence of the disease and progression to chronic interstitial lung disease can occur among survivors.

↑ Vourlekis JS, Brown KK, Schwarz MI (August 2001). "Acute interstitial pneumonitis: current understanding regarding diagnosis, pathogenesis, and natural history". Semin Respir Crit Care Med. 22 (4): 399–408. doi:10.1055/s-2001-17383. PMID 16088688.
↑ Matthay MA, Zimmerman GA (October 2005). "Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management". Am. J. Respir. Cell Mol. Biol. 33 (4): 319–27. doi:10.1165/rcmb.F305. PMC 2715340. PMID 16172252.
↑ Avnon LS, Pikovsky O, Sion-Vardy N, Almog Y (January 2009). "Acute interstitial pneumonia-Hamman-Rich syndrome: clinical characteristics and diagnostic and therapeutic considerations". Anesth. Analg. 108 (1): 232–7. doi:10.1213/ane.0b013e318188af7a. PMID 19095855.
↑ Parambil JG, Myers JL, Aubry MC, Ryu JH (July 2007). "Causes and prognosis of diffuse alveolar damage diagnosed on surgical lung biopsy". Chest. 132 (1): 50–7. doi:10.1378/chest.07-0104. PMID 17475632.