Hematopoiesis lineages

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Lineages

Blood cells are divided into three lineages: Erythroid, Lymphoid, Myeloid. Granulopoiesis is hematopoiesis of granulocytes.

All blood cells are divided into three lineages.

• Erythroid cells are the oxygen carrying red blood cells.
• Lymphoid cells are the cornerstone of the adaptive immune system. They are derived from common lymphoid progenitors. The lymphoid lineage is primarily composed of T-cells and B-cells. (white blood cells)
• Myeloid cells, which includes granulocytes, megakaryocytes, and macrophages, are derived from common myeloid progenitors, and are involved in such diverse roles as innate immunity, adaptive immunity, and blood clotting.

Simple diagram that shows the development of different blood cells from hematopoietic stem cell to mature cells

Comprehensive diagram that shows the development of different blood cells from hematopoietic stem cell to mature cells

Granulopoiesis

Granulopoiesis (or granulocytopoiesis) is hematopoiesis of granulocytes.

It occurs primarily within bone marrow.

It involves the following stages:

• Pluripotential hemopoietic stem cell
• Myeloblast
• Promyelocyte
• Eosino/neutro/basophilic myelocyte
• Metamyelocyte
• Band cell
• Granulocytes (Eosino/neutro/basophil)