Hereditary nonpolyposis colorectal cancer epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]Ali Akram, M.B.B.S.[3]
Overview
Incidence of HNPCC is not well known but it is estimated that 0.5 to 13% of the cases of colorectal cancer are due to hereditary nonpolyposis colorectal cancer. The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2 - 7% of all the diagnosed cases of colorectal cancer. Hereditary nonpolyposis colorectal cancer commonly affects young adult population. The median age of diagnosis is between 40 to 45 years. Hereditary nonpolyposis colorectal cancer affects males and females equally. Hereditary nonpolyposis colorectal cancer usually affects individuals of the white race more commonly. Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.
Epidemiology and Demographics
Incidence
- Incidence of HNPCC is not well known but it is estimated that 0.5 to 13% of the cases of colorectal cancer are due to hereditary nonpolyposis colorectal cancer.[1][2]
Prevalence
- The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2 - 7% of all the diagnosed cases of colorectal cancer.[3]
Age
- Hereditary nonpolyposis colorectal cancer commonly affects young adult population.
- The median age of diagnosis is often less than 45 years.[3]
Gender
- Hereditary nonpolyposis colorectal cancer affects males and females equally.
- In some particular genetic mutations such as MLH1, males have significantly higher risk than females at all ages.[3]
Race
- Hereditary nonpolyposis colorectal cancer usually affects individuals of the white race more commonly.
- Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.
References
- ↑ Aaltonen LA, Sankila R, Mecklin JP, Järvinen H, Pukkala E, Peltomäki P; et al. (1994). "A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden". Cancer Detect Prev. 18 (1): 57–63. PMID 8162607.
- ↑ Houlston RS, Collins A, Slack J, Morton NE (1992). "Dominant genes for colorectal cancer are not rare". Ann Hum Genet. 56 (Pt 2): 99–103. PMID 1503398.
- ↑ 3.0 3.1 3.2 Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A (1998). "Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease". N. Engl. J. Med. 338 (21): 1481–7. doi:10.1056/NEJM199805213382101. PMID 9593786.