Hitachimycin

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Hitachimycin
	File:Hitachimycin.png
Identifiers
	IUPAC name (2Z,4E,6E,12E)-16,20-dihydroxy-21-methoxy-; 3-methyl-10-phenyl-9-azabicyclo[17.3.0]; docosa-2,4,6,12,19-pentaene-8,18-dione;
CAS Number	77642-19-4;
PubChem CID	5384563;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C29H35NO5
Molar mass	477.592 g/mol

Hitachimycin, also known as stubomycin, is a cyclic polypeptide produced by Streptomyces that acts as an antibiotic. It exhibits cytotoxic activity against mammalian cells, Gram-positive bacteria, yeast, and fungi, as well as hemolytic activity; this is mediated by changes at the cell membrane and subsequent lysis.^[1] Owing to its cytotoxic activity against mammalian cells and tumors, it was first proposed as a antitumor antibiotic.^[2]

As of 2007, it has not been used in a clinical setting.

References

↑ Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I (1983). "Studies on the biological activity of stubomycin". J. Antibiot. 36 (3): 301–11. PMID 6833150.
↑ Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M (1981). "A new antitumor antibiotic, stubomycin". J. Antibiot. 34 (3): 259–65. PMID 7275806.

Template:PolypeptideAntiBiotics

Template:WH Template:WikiDoc Sources

[1] Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I (1983). "Studies on the biological activity of stubomycin". J. Antibiot. 36 (3): 301–11. PMID 6833150.

[2] Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M (1981). "A new antitumor antibiotic, stubomycin". J. Antibiot. 34 (3): 259–65. PMID 7275806.

[1]

[2]

Identifiers
File:Hitachimycin.png
IUPAC name (2Z,4E,6E,12E)-16,20-dihydroxy-21-methoxy- 3-methyl-10-phenyl-9-azabicyclo[17.3.0] docosa-2,4,6,12,19-pentaene-8,18-dione
CAS Number	77642-19-4
PubChem CID	5384563
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₉H₃₅NO₅
Molar mass	477.592 g/mol

Hitachimycin

References

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