Human menopausal gonadotropin
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| Trade names | Repronex |
| MedlinePlus | a601002 |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Menotropin (also called human menopausal gonadotropin or hMG) is a hormonally active medication for the treatment of fertility disturbances. Frequently the plural is used as the medication is a mixture of gonadotropins. Menotropins are extracted from the urine of postmenopausal women.[1]
Description and usage
Urine of postmenopausal women reflects the hypergonadotropic state of menopause -levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) are high - and contain a mixture of these gonadotropins.[2][3][4] Other protein substances may be present, including small amounts of human chorionic gonadotropin (hCG).[1] In 1949 Piero Donini found a relatively simple method to extract gonadotropins from urine of postmenopausal women.[4][5] Menotropins were successfully introduced into clinical use by Bruno Lunenfeld in 1961.[4] While earlier menotropin medications contained FSH and LH at a 1:1 ratio, the recognition that it is FSH that is critical for follicle stimulation has led to development of newer preparations that contain a much higher FSH/LH ratio, Fertinex being an example.[4]
Menotropin preparations are designed for use in selected women where they stimulate the ovaries to mature follicles, thus making them more fertile. They are administered by typically daily injection, intramuscularly or subcutaneously, for about ten days under close supervision to adjust dose and duration of therapy. They can also be used in hypogonadal men to stimulate sperm production.
Human urinary-derived menotropin preparations are exposed to the theoretical risk of infection from menopausal donors of urine. Nevertheless, the failure to irrefutably demonstrate infectivity following intracerebral inoculation with urine from transmissible spongiform encephalopathy(TSE)-infected hosts suggests that the risk associated with products derived from urine is merely theoretical.[6]
Recombinant gonadotropins have to a large degree replaced hMG in fertility treatments. The recombinant process allows for the production of pure FSH or LH not "contaminated" by other proteins that may be present after urinary extraction. While some head-on studies seem not to suggest that "pure FSH" gives better results than hMG.,[7] others claim that recombinant FSH is more efficient and reduces costs.[8] A Cochrane Collaboration analysis did not reveal major differences in clinical outcomes when comparing urinary versus recombinant FSH.[9]
The Practice Committee of the American Society for Reproductive Medicine reported:[10] “Compared with earlier crude animal extracts, modern highly purified urinary and recombinant gonadotropin products have clearly superior quality, specific activity, and performance. There are no confirmed differences in safety, purity, or clinical efficacy among the various available urinary or recombinant gonadotropin products.”
List of hMG preparations
A number of drug companies have and had marketed hMG preparations that include:[11]
- Humegon (Organon),
- Menopur (Ferring Pharmaceuticals), 75 IU FSH and 75 IU LH activity
- Menogon,
- Metrodin (Serono),
- highly purified urinary FSH
- Repronex (Ferring Pharmaceuticals), 75 IU FSH and 75 IU LH
- Pergonal (Serono),
- Pergonal was the major hMG prior to the arrival of recombinant gonadotropins containing 75 IU FSH and 75 IU LH. The first successful in-vitro fertilization in 1978 was achieved after follicle stimulation with the use of Pergonal.[5]
- HMG Massone, 75 IU FSH and 75 IU LH
See also
References
- ↑ 1.0 1.1 PMID 14680547 (PMID 14680547)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ Menotropins at the US National Library of Medicine Medical Subject Headings (MeSH)
- ↑ TheFreeDictionary > Menotropin Citing: Dorland's Medical Dictionary for Health Consumers. 2007
- ↑ 4.0 4.1 4.2 4.3 Lunenfeld B. "Historical perspectives in gonadotropin therapy". Human reproductive Update 2004, 10 (6):453-467. doi:10.1093/humupd/dmh044. Retrieved 2013-11-25.
- ↑ 5.0 5.1 Unknown. "Serono goes recombinant". Serono Laboratories, 2011. Retrieved 2013-11-24.
- ↑ Reichl H, Balen A, Jansen CA (October 2002). "Prion transmission in blood and urine: what are the implications for recombinant and urinary-derived gonadotrophins?". Hum. Reprod. 17 (10): 2501–8. doi:10.1093/humrep/17.10.2501. PMID 12351519.
- ↑ PMID 9513843 (PMID 9513843)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 11726575 (PMID 11726575)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 21328276 (PMID 21328276)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ Practice Committee Of American Society For Reproductive Medicine, Birmingham (November 2008). "Gonadotropin preparations: past, present, and future perspectives". Fertil. Steril. 90 (5 Suppl): S13–20. doi:10.1016/j.fertnstert.2008.08.031. PMID 19007609.
- ↑ Fuller, Matthew A.; Martha Sajatovic (2003). Drug Information Handbook for Psychiatry (4 ed.). Lexi-Comp, Inc. p. 711. ISBN 1-59195-064-3.
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