Hydroxyzine/reference table

General classification Antihistamine -- Competitive antagonist of histamine, H1 histamine receptor and antiemetic, anxiolytic. Prescriptive conditions Alcohol withdrawal anxiety Anxiety manifested by organic disease states Nausea or nauseating conditions Forms Syrup Oral Suspension Tablet form Capsule form

Onset and duration Oral administration onset: 15-30 minutes Suppression of wheal & flare response to allergenic skin extract: 4 days. Serum level Pruritus: 6-42 μg/L (14-102 nmol/L) (Suppresses pruritus in children) Fate Peak serum level Healthy adults -- 73 ± 11 μg/L occurs 2 ± 0.4 hr after a 0.7 mg/kg dose Primary biliary cirrhosis -- 117 ± 61 μg/L at 2.3 ± 0.7 hr after 44mg mean dose Vd Children -- 19 ±9 L/kg Healthy adults -- 16 ± 3 L/kg Elderly -- 23 ± 6 L/kg Primary biliary cirrhosis -- 23 ±13 L/kg Cl Children -- 1.9 L/hr/kg Healthy young/elderly adults -- 0.6 ± 0.2 L/hr/kg Primary biliary cirrhosis -- 0.5 ±0.4 L/hr/kg t½ Children -- 7hr (increases with age) Healthy adults -- 20 ± 4 hr Elderly -- 29 ± 10 hr Primary biliary cirrhosis -- 37 ±13 hr