Hyperchloremia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Elevations in chloride may be associated with diarrhea, certain kidney diseases, and overactivity of the parathyroid glands. Hyperchloremia is often comorbid with diabetes or hyponatremia. Certain drugs, especially diuretics such as carbonic anhydrase inhibitors, hormonal treatments, and polypharmacy, may contribute to this disorder.

Causes

Causes by Organ System

Cardiovascular	No underlying causes
Chemical / poisoning	Drugs
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	Hyperparathyroidism
Environmental	No underlying causes
Gastroenterologic	Ileul loops, Loss of pancreatic secretion, Prolonged diarrhea, Ureteral colonic anastomosis
Genetic	No underlying causes
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal / Ortho	No underlying causes
Neurologic	No underlying causes
Nutritional / Metabolic	Dehydration, Hypernatremia, Metabolic acidosis
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Opthalmologic	No underlying causes
Overdose / Toxicity	Drugs
Psychiatric	No underlying causes
Pulmonary	Respiratory alkalosis
Renal / Electrolyte	Artifact (low anion gap), Dehydration, Hypernatremia, Metabolic acidosis, Nephrotic syndrome, Renal failure, Renal tubular acidosis, Respiratory alkalosis
Rheum / Immune / Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	Nephrotic syndrome, Renal failure, Renal tubular acidosis, Ureteral colonic anastomosis
Miscellaneous	No underlying causes

Causes in Alphabetical Order

• Artifact (low anion gap)
• Dehydration
• Drugs
• Hypernatremia
• Hyperparathyroidism
• Ileul loops
• Loss of pancreatic secretion
• Metabolic acidosis
• Nephrotic syndrome
• Prolonged diarrhea
• Renal failure
• Renal tubular acidosis
• Respiratory alkalosis
• Ureteral colonic anastomosis