Hypercholesterolemia causes

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Lipoprotein Disorders Main Page

Hyperlipoproteinemia Microchapters

Hypercholesterolemia Patient Information

Hypertriglyceridemia Patient Information

Overview

Classification

Familial hyperchylomicronemia
Familial hypercholesterolemia
Familial combined hyperlipidemia
Dysbetalipoproteinemia
Primary hypertriglyceridemia
Mixed hyperlipoproteinemia

Differential Diagnosis

Screening

ACC/AHA Guideline Recommendations

Summary

Treatment

Major recommendations for statin therapy

Therapeutic response to statin therapy

Blood cholesterol LDL and non-HDL treatment goals

Treatment in heart failure and hemodialysis

Primary prevention

Secondary prevention

Intensity of statin therapy in primary and secondary prevention

Safety Recommendations

Guideline on Lifestyle Management

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.

Overview

Hypercholesterolemia is primarily caused by cardiovascular conditions resulting from lifestyle, renal disease, and congenital conditions.

Causes

Common Causes

Causes by Organ System

Cardiovascular Abetalipoproteinemia , ApoA1 deficiency, Apob mutation, Apolipoprotein c-ii deficiency, Apoprotein e deficiency, Beta blockers, Cholesterol ester storage disease, Ldl receptor deficiency, Ldlr mutation, Ldlrap1 mutation, Lipoprotein lipase deficiency
Chemical/Poisoning Alcohol, Retinoic acid, Tobacco
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Ciclosporin, Fosamprenavir, Glucocorticoids, Medications, Mitotane, Siltuximab, Sirolimus, Temsirolimus, Thiazide diuretics, Tocilizumab, Tofacitinib
Ear Nose Throat No underlying causes
Endocrine Cushing’s syndrome, Glycogenosis type 1a, Glycogenosis type 3, Glycogenosis type 6, Hypothyroidism
Environmental No underlying causes
Gastroenterologic Alagille syndrome, Analbuminaemia, Cholestatic jaundice, Glycogenosis type 1a, Glycogenosis type 3, Glycogenosis type 6, Malignant hepatopathy, Obstructive liver disease, Zieve's syndrome
Genetic Abetalipoproteinemia , Alström syndrome, Beckwith-wiedemann syndrome, Chromosome 14 uniparental disomy syndrome , Chromosome 3, trisomy 3p, Familial defective apolipoprotein b-100, Familial mixed hyperlipidaemia, Pcsk9 mutation, Werner syndrome
Hematologic Analbuminaemia, ApoA1 deficiency, Apob mutation, Apolipoprotein c-ii deficiency, Apoprotein e deficiency, Beta blockers, Cholesterol ester storage disease, Familial defective apolipoprotein b-100, Familial mixed hyperlipidaemia, Ldl receptor deficiency, Ldlr mutation, Ldlrap1 mutation, Lipoprotein lipase deficiency, Monoclonal gammopathy, Pcsk9 mutation
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Carbohydrate intake, Diabetes mellitus type 2, Diabetes mellitus, Lack of exercise, Lack of physical activity, Metabolic syndrome, Obesity, Trans fatty acids, Vitamin e deficiency
Obstetric/Gynecologic Pregnancy
Oncologic Carcinoma, Cholestatic jaundice
Ophthalmologic Oculomotor apraxia syndrome
Overdose/Toxicity Alcohol, Zieve's syndrome
Psychiatric Anorexia nervosa
Pulmonary No underlying causes
Renal/Electrolyte Chronic renal insufficiency, Dialysis, Malignant hepatopathy, Nephrotic syndrome
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma Dialysis
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

References

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