Hypoaldosteronism causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]
Overview
The most common cause of hypoaldosteronism is diabetic nephropathy. Other common causes are acute glomerulonephritis, tuberculosis, hemorrhage, infarction, sarcoidosis, AIDS, CMV, and Addison's disease. Less common causes of hypoaldosteronism include sarcoidosis, amyloidosis, fungal infections, AIDS complications, and hemochromatosis.
Causes
Life-threatening Causes
Life-threatening causes of hypoaldosteronism include:[1]
- Adrenal infarction
- Bilateral adrenal hemorrhage (caused by trauma, anticoagulant therapy, or coagulation disorders).
- Cancerous destruction of the adrenal gland, secondary to infiltrative or metastatic disease.
- Tubercular and fungal destruction of adrenal glands.
Common Causes
Common causes of hypoaldosteronism include:[2]
- Diabetic nephropathy
- Acute glomerulonephritis
- Any cause of renal insufficiency
- Autoimmune/Idiopathic
- Tuberculosis
- AIDS
- CMV
- Hemorrhage into adrenal glands
- Adrenal gland Infarction
- Sarcoidosis
Less common causes
Less common causes of hypoaldosteronism include:
- Amyloidosis
- Fungal infections
- Hemochromatosis
- Polyglandular endocrine syndromes
- Adrenoleukodystrophy
- Adrenomyelodystrophy
Drugs causing hypoaldosteronism
Other less common causes of hypoaldosteronism include drugs such as:[3][4][5][6][7]
| Decreased renin release | Inhibition of
aldosterone synthase |
Decreased production
of aldosterone |
Decreased effect of
aldosterone |
Drugs that impair
adrenal function |
Direct inhibition
of zona glomerulosa |
Dopaminergic agonists |
|---|---|---|---|---|---|---|
|
References
- ↑ LaBan MM, Whitmore CE, Taylor RS (2003). "Bilateral adrenal hemorrhage after anticoagulation prophylaxis for bilateral knee arthroplasty". Am J Phys Med Rehabil. 82 (5): 418–20. doi:10.1097/01.PHM.0000064741.97586.E4. PMID 12704285.
- ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:14-15
- ↑ Missale C, Lombardi C, De Cotiis R, Memo M, Carruba MO, Spano PF (1989). "Dopaminergic receptor mechanisms modulating the renin-angiotensin system and aldosterone secretion: an overview". J. Cardiovasc. Pharmacol. 14 Suppl 8: S29–39. PMID 2483440.
- ↑ Akizuki O, Inayoshi A, Kitayama T, Yao K, Shirakura S, Sasaki K, Kusaka H, Matsubara M (2008). "Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R". Eur. J. Pharmacol. 584 (2–3): 424–34. doi:10.1016/j.ejphar.2008.02.001. PMID 18331727.
- ↑ Ikeda, Keiichi; Isaka, Tsuyoshi; Fujioka, Kouki; Manome, Yoshinobu; Tojo, Katsuyoshi (2012). "Suppression of Aldosterone Synthesis and Secretion by Channel Antagonists". International Journal of Endocrinology. 2012: 1–6. doi:10.1155/2012/519467. ISSN 1687-8337.
- ↑ McKenna TJ, Island DP, Nicholson WE, Liddle GW (1978). "The effects of potassium on early and late steps in aldosterone biosynthesis in cells of the zona glomerulosa". Endocrinology. 103 (4): 1411–6. doi:10.1210/endo-103-4-1411. PMID 744152.
- ↑ Carey, R. M.; Drake, C. R. (1986). "Dopamine selectively inhibits aldosterone responses to angiotensin II in humans". Hypertension. 8 (5): 399–406. doi:10.1161/01.HYP.8.5.399. ISSN 0194-911X.