IFI30

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Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that in humans is encoded by the IFI30 gene.^[1]^[2]^[3]

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.^[3]

References

↑ Luster AD, Weinshank RL, Feinman R, Ravetch JV (Sep 1988). "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem. 263 (24): 12036–43. PMID 3136170.
↑ Arunachalam B, Phan UT, Geuze HJ, Cresswell P (Mar 2000). "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A. 97 (2): 745–50. doi:10.1073/pnas.97.2.745. PMC 15401. PMID 10639150.
↑ ^3.0 ^3.1 "Entrez Gene: IFI30 interferon, gamma-inducible protein 30".

Csányi E (1977). "[Endre Kótai; 1914-1976]". Magyar traumatológia, orthopaedia és helyreállító sebészet. 20 (1): 1. PMID 16170.
Sabin NM (1977). "Letters to the editors". The Journal of the Wisconsin Dental Association. 52 (1): 9. PMID 1069150.
Phan UT, Arunachalam B, Cresswell P (2000). "Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action". J. Biol. Chem. 275 (34): 25907–14. doi:10.1074/jbc.M003459200. PMID 10852914.
Phan UT, Maric M, Dick TP, Cresswell P (2001). "Multiple species express thiol oxidoreductases related to GILT". Immunogenetics. 53 (4): 342–6. doi:10.1007/s002510100323. PMID 11491538.
Haque MA, Li P, Jackson SK, et al. (2002). "Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes". J. Exp. Med. 195 (10): 1267–77. doi:10.1084/jem.20011853. PMC 2193747. PMID 12021307.
Phan UT, Lackman RL, Cresswell P (2002). "Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12298–303. doi:10.1073/pnas.182430499. PMC 129439. PMID 12198183.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid3136170-1] Luster AD, Weinshank RL, Feinman R, Ravetch JV (Sep 1988). "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem. 263 (24): 12036–43. PMID 3136170.

[pmid10639150-2] Arunachalam B, Phan UT, Geuze HJ, Cresswell P (Mar 2000). "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A. 97 (2): 745–50. doi:10.1073/pnas.97.2.745. PMC 15401. PMID 10639150.

[entrez-3] 3.0 ^3.1 "Entrez Gene: IFI30 interferon, gamma-inducible protein 30".

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[2]

[3]

IFI30

References

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