ITSN2

Intersectin 2
PDB rendering based on 1j3t.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1j3t​, 1udl​, 1ue9​, 1uff​, 1uhf​
Identifiers
Symbols	ITSN2 ; SWAP; KIAA1256; SH3D1B; SH3P18; SWA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22627
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Intersectin 2, also known as ITSN2, is a human gene.

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined.

Further reading

• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sparks AB, Hoffman NG, McConnell SJ; et al. (1998). "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins". Nat. Biotechnol. 14 (6): 741–4. doi:10.1038/nbt0696-741. PMID 9630982.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Kikuno R; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. PMID 10574462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pucharcos C, Estivill X, de la Luna S (2000). "Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis". FEBS Lett. 478 (1–2): 43–51. PMID 10922467.CS1 maint: Multiple names: authors list (link)
• Pucharcos C, Casas C, Nadal M; et al. (2001). "The human intersectin genes and their spliced variants are differentially expressed". Biochim. Biophys. Acta. 1521 (1–3): 1–11. PMID 11690630.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McGavin MK, Badour K, Hardy LA; et al. (2002). "The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis". J. Exp. Med. 194 (12): 1777–87. PMID 11748279.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chini CC, Chen J (2003). "Human claspin is required for replication checkpoint control". J. Biol. Chem. 278 (32): 30057–62. doi:10.1074/jbc.M301136200. PMID 12766152.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brill LM, Salomon AR, Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
• Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Wolf-Yadlin A, Ross PL; et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishimura T, Yamaguchi T, Tokunaga A; et al. (2006). "Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2". Mol. Biol. Cell. 17 (3): 1273–85. doi:10.1091/mbc.E05-07-0700. PMID 16394100.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seifert M, Ampofo C, Mehraein Y; et al. (2007). "Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain". Oncol. Rep. 17 (5): 1207–11. PMID 17390067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim CS, Seet BT, Ingham RJ; et al. (2007). "The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction". Biochemistry. 46 (35): 9874–85. doi:10.1021/bi700357s. PMID 17696407.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)