Idiopathic infantile arterial calcification medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayokunle Olubaniyi, M.B,B.S [2]
Overview
Medical treatment
- Prenatal[1] and postnatal treatment with low-dose, cyclical bisphosphonates, also called diphosphonate, resulted in a complete resolution of vascular calcifications in some cases using disodium pamidronate and risedronate.[2][3][4][3][5][6]
- PGE1 infusion is a possible therapeutic alternative for babies with idiopathic arterial calcification complicated by severe hypertension refractory to conventional treatment.[7]
- Infants must reach a certain weight to allow for a transplant, commonly not reached.[8]
References
- ↑ Bellah, Richard D.; Zawodniak, Len; Librizzi, Ronald J.; Harris, Mary Catherine (1992). "Idiopathic arterial calcification of infancy: Prenatal and postnatal effects of therapy in an infant". The Journal of Pediatrics. 121 (6): 930–3. doi:10.1016/S0022-3476(05)80345-2. PMID 1447660.
- ↑ Ramjan, Kim A; Roscioli, Tony; Rutsch, Frank; Sillence, David; Munns, Craig FJ (2009). "Generalized arterial calcification of infancy: Treatment with bisphosphonates". Nature Clinical Practice Endocrinology & Metabolism. 5 (3): 167–72. doi:10.1038/ncpendmet1067.
- ↑ 3.0 3.1 Dyck, M.; Proesmans, W.; Hollebeke, E.; Marchal, G.; Moerman, Ph. (1989). "Idiopathic infantile arterial calcification with cardiac, renal and central nervous system involvement". European Journal of Pediatrics. 148 (4): 374–7. doi:10.1007/BF00444138. PMID 2707283.
- ↑ Ramjan, Kim; Munns, Craig; Roscioli, Tony; Sillence, David. "Successful treatment of infantile arterial calcification (IAC) with bisphosphonates" (PDF).[unreliable medical source?]
- ↑ Sluis, Inge M.; Boot, Annemieke M.; Vernooij, Meike; Meradji, Morteza; Kroon, André A. (2006). "Idiopathic infantile arterial calcification: Clinical presentation, therapy and long-term follow-up". European Journal of Pediatrics. 165 (9): 590–3. doi:10.1007/s00431-006-0146-8. PMID 16649023.
- ↑ Culling, Bronwyn; Loughran-Fowlds, Alison; Munns, Craig; Sillence, David; Walsh, Corrina; Taylor, Peter; Buckley, Michael; Rutsch, Frank; Roscioli, Tony (August 6–10, 2006). Infantile Arterial Calcification: Successful Treatment with Bisphosphonate. 11th International Congress of Human Genetics. Brisbane, Australia. Archived from the original on May 12, 2006.
- ↑ Ciana, G.; Colonna, F.; Forleo, V.; Brizzi, F.; Benettoni, A.; de Vonderweid, U. (1997). "Idiopathic Arterial Calcification of Infancy: Effectiveness of Prostaglandin Infusion for Treatment of Secondary Hypertension Refractory to Conventional Therapy: Case Report". Pediatric Cardiology. 18 (1): 67–71. doi:10.1007/s002469900114. PMID 8960499.
- ↑ Glatz, Andrew C.; Pawel, Bruce R.; Hsu, Daphne T.; Weinberg, Paul; Chrisant, Maryanne R. K. (2006). "Idiopathic infantile arterial calcification: Two case reports, a review of the literature and a role for cardiac transplantation". Pediatric Transplantation. 10 (2): 225–33. doi:10.1111/j.1399-3046.2005.00414.x. PMID 16573612.