Idiopathic interstitial pneumonia laboratory findings
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Differentiating Idiopathic interstitial pneumonia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Overview
Laboratory and Serological Tests
Blood work-up are not that helpful in diagnosing Idiopathic Interstitial Pneumonia. However, a few common abnormalities are mentioned below.
- ESR is elevated in cases casued due to connective tissue disorders.
- Presence of Antinuclear antibodies and high positive titres (>1:160) of Rheumatoid factor may suggest an Autoimmune cause .[1][2][3][4][5][6]
- Polycythemia may be seen late due to hypoxemia.
- Hypergammaglobulinemia
- Increased levels of LDH may be seen in a few cases which is non specific .
Pulmonary Function Tests
Invasive tests
Bronchioalveolar Lavage
Lung Biopsy
References
- ↑ Nagaya, H.; Buckley, CE.; Sieker, HO. (1969). "Positive antinuclear factor in patients with unexplained pulmonary fibrosis". Ann Intern Med. 70 (6): 1135–45. PMID 4892605. Unknown parameter
|month=ignored (help) - ↑ Nagaya, H.; Sieker, HO. (1972). "Pathogenetic mechanisms of interstitial pulmonary fibrosis in patients with serum antinuclear factor. A histologic and clinical correlation". Am J Med. 52 (1): 51–62. PMID 4536709. Unknown parameter
|month=ignored (help) - ↑ Turner-Warwick, M.; Haslam, P.; Weeks, J. (1971). "Antibodies in some chronic fibrosing lung diseases. II. Immunofluorescent studies". Clin Allergy. 1 (2): 209–19. PMID 4950528. Unknown parameter
|month=ignored (help) - ↑ Chapman, JR.; Charles, PJ.; Venables, PJ.; Thompson, PJ.; Haslam, PL.; Maini, RN.; Turner Warwick, ME. (1984). "Definition and clinical relevance of antibodies to nuclear ribonucleoprotein and other nuclear antigens in patients with cryptogenic fibrosing alveolitis". Am Rev Respir Dis. 130 (3): 439–43. PMID 6433759. Unknown parameter
|month=ignored (help) - ↑ Dreisin, RB.; Schwarz, MI.; Theofilopoulos, AN.; Stanford, RE. (1978). "Circulating immune complexes in the idiopathic interstitial pneumonias". N Engl J Med. 298 (7): 353–7. doi:10.1056/NEJM197802162980701. PMID 146160. Unknown parameter
|month=ignored (help) - ↑ GOTTLIEB, AJ.; SPIERA, H.; TEIRSTEIN, AS.; SILTZBACH, LE. (1965). "SEROLOGIC FACTORS IN IDIOPATHIC DIFFUSE INTERSTITIAL PULMONARY FIBROSIS". Am J Med. 39: 405–10. PMID 14338291. Unknown parameter
|month=ignored (help)