Insulinoma history and symptoms
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]
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Overview
A positive long history of frequent episodes of altered mental status/confusion, visual disturbances and sweating is suggestive of insulinoma. The most common symptoms of insulinoma include altered mental status/confusion, visual disturbances like blurred vision/diplopia, sweating, hyperphagia and coma. Less common symptoms of insulinoma include palpitations, seizures, tremors, behavioral disturbances and weakness.
History and Symptoms
Insulinoma patients usually present with history of hypoglycemic episodes occurring over time with a recent increase in frequency and without any other cause known to cause hypoglycemia like exogenous insulin and hypoglycemic agents. The following are the history and symptoms of insulinoma:
History
Patients with insulinoma may have a positive history of:
- Frequent episodes of altered mental status/confusion
- Visual disturbances
- Sweating
- Negative history for exogenous insulin or oral hypoglycemic agents such as Sulfonylureas
Common Symptoms
Common symptoms of insulinoma include: [1][2]
- Altered mental status/confusion
- Visual disturbances like blurred vision/diplopia
- Sweating
- Hyperphagia
- Coma
Less Common Symptoms
Less common symptoms of insulinoma include
- Palpitations
- Seizures
- Tremors
- Behavioral disturbances
- Weakness
| Neuroglycopenic symptoms | |
| Visual disturbances | 59% |
| Altered mental status/Confusion | 75-80% |
| Behavioral problems | 36% |
| Weakness | 24-32% |
| Coma | 47% |
| Seizures | 36% |
| Sympathetic or Adrenergic symptoms | |
| Sweating | 12-69% |
| Palpitations | 10-12% |
| Tremors | 17-24% |
| Hyperphagia/Obesity | 25-50% |
References
- ↑ Metz DC, Jensen RT (2008). "Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors". Gastroenterology. 135 (5): 1469–92. doi:10.1053/j.gastro.2008.05.047. PMC 2612755. PMID 18703061.
- ↑ Boukhman MP, Karam JH, Shaver J, Siperstein AE, Duh QY, Clark OH (1998). "Insulinoma--experience from 1950 to 1995". West J Med. 169 (2): 98–104. PMC 1305178. PMID 9735690.