Intussusception causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2]

Overview

Common causes of intussusception in children can be divided into idiopathic and pathologic. Idiopathic causes include seasonal viral gastroenteritis, rotavirus vaccine, adenovirus infection, and bacterial enteritis. Pathologic causes of intussusception in children include Henoch-Schonlein purpura, cystic fibrosis, Celiac disease, Crohn's disease, Meckel's diverticulum, polyps, duplication cysts, and lymphoma. Intussusception in adults is mostly due to a pathologic lead point. Non-idiopathic intestinal causes for intussusception in adults can further be divided into benign and malignant enteric causes, and benign and malignant colonic causes.

Children

Idiopathic- no lead point

Pathologic- Lead point

Causes of nonidiopathic adult intestinal intussusception*
Enteric (benign)	Enteric (malignant)	Colonic (benign)	Colonic (malignant)
Adhesions Adenoma Celiac disease Crohn's disease Endometriosis Malignant stromal (GIST) tumor Hamartoma Hemangioma Inflammatory polyp Kaposi's sarcoma Lipoma Meckel's diverticulum Neurofibroma Peutz–Jegher polyp Tuberculosis Submucosal hemorrhages from unregulated anticoagulation	Adenocarcinoma Carcinoid tumor Leiomyosarcoma Lymphoma Metastatic carcinoma (melanoma most common) Malignant GIST Neuroendocrine tumor	Adenoma Inflammatory pseudopolyp Lipoma	Adenocarcinoma Lymphoma Sarcoma

*Adopted from Clinics in Colon and Rectal Surgery 2017^[7]

↑ Buettcher M, Baer G, Bonhoeffer J, Schaad UB, Heininger U (2007). "Three-year surveillance of intussusception in children in Switzerland". Pediatrics. 120 (3): 473–80. doi:10.1542/peds.2007-0035. PMID 17766518.
↑ Shimabukuro TT, Nguyen M, Martin D, DeStefano F (2015). "Safety monitoring in the Vaccine Adverse Event Reporting System (VAERS)". Vaccine. 33 (36): 4398–405. doi:10.1016/j.vaccine.2015.07.035. PMC 4632204. PMID 26209838.
↑ Bines JE, Liem NT, Justice FA, Son TN, Kirkwood CD, de Campo M, Barnett P, Bishop RF, Robins-Browne R, Carlin JB (2006). "Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus". J. Pediatr. 149 (4): 452–60. doi:10.1016/j.jpeds.2006.04.010. PMID 17011313.
↑ Ebert EC (2008). "Gastrointestinal manifestations of Henoch-Schonlein Purpura". Dig. Dis. Sci. 53 (8): 2011–9. doi:10.1007/s10620-007-0147-0. PMID 18351468.
↑ Cohen DM, Conard FU, Treem WR, Hyams JS (1992). "Jejunojejunal intussusception in Crohn's disease". J. Pediatr. Gastroenterol. Nutr. 14 (1): 101–3. PMID 1573498.
↑ López-Tomassetti Fernández EM, Lorenzo Rocha N, Arteaga González I, Carrillo Pallarés A (2006). "Ileoileal intussusception as initial manifestation of Crohn's disease". Mcgill J Med. 9 (1): 34–7. PMC 2687895. PMID 19529808.
↑ "Thieme E-Journals - Clinics in Colon and Rectal Surgery / Abstract".