KIZ (gene)

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Kizuna centrosomal protein is a protein that in humans is encoded by the KIZ gene.

Function

The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].

Clinical significance

Mutations in KIZ cause Rod-cone dystrophy (RCD) .

Further reading

• Oshimori N, Li X, Ohsugi M, Yamamoto T (2009). "Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation". EMBO J. 28 (14): 2066–76. doi:10.1038/emboj.2009.161. PMC 2718283. PMID 19536135.
• Oshimori N, Ohsugi M, Yamamoto T (2006). "The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity". Nat. Cell Biol. 8 (10): 1095–101. doi:10.1038/ncb1474. PMID 16980960.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.