Knee pain

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.

Causes

Life Threatening Causes

• Acute leukemia
• Bleeding disorders
• Bone tumors
• Dermatomyositis
• Knee bacterial infection
• Knee tumor
• Malignant bone tumor
• Syphilis
• Viral infections

Common Causes

• Anterior cruciate ligament tear
• Articular cartilage injury
• Baker's cyst
• Bone contusion
• Bone tumors
• Brodie knee 
• Bursitis
• Chondromalacia patella
• Crystal arthropathy
• Degenerative medial meniscal tear 
• Dislocated knee
• Dislocated patella
• Epiphyseal dysplasia
• Fairbank disease
• Fallen arches 
• Femoral condyle fracture
• Fibular head or neck fracture
• Fractured patella
• Fractured tibial plateau
• Gait problems
• Hemarthrosis
• Hip conditions 
• Hip dislocation
• Hip injury 
• Hip replacement 
• Hoffa disease
• Housemaid's knee
• Howship-romberg sign
• Hypertrophic pulmonary osteoarthropathy periostitis
• Hypophosphatemic rickets
• Iliotibial band syndrome
• Intermittent hydrarthrosis
• Intra-articular fracture
• Jaffe-lichtenstein-sutro syndrome 
• Johansson-sinding-larsen syndrome
• Joint injury
• Juvenile chronic arthritis
• Juvenile paget's disease 
• Knee arthritis
• Knee bacterial infection
• Knee bursitis
• Knee conditions
• Knee cyst
• Knee dislocation
• Knee fracture
• Knee infection
• Knee inflammation
• Knee injury 
• Knee overuse
• Knee sprain 
• Knee strain
• Knee tendinitis 
• Knee tumor
• Knock knees
• Lateral knee pain 
• Malignant bone tumor
• Medial ligament injury
• Medial ligament tear
• Meniscal pathology
• Meniscus injury 
• Meniscus tear
• Neisseria gonorrhoeae
• Neuropathic knee joint
• Osgood-schlatter disease
• Osteoarthritis
• Osteochondritis dissecans
• Osteochondrosis
• Paget's disease
• Patella dislocation or significant subluxation
• Patella fracture
• Patella stress fracture
• Patella subluxation
• Patella tendon tear
• Patellar tendinitis
• Patellar tendinopathy
• Patellofemoral pain
• Pellegrini-stieda syndrome
• Pes anserine bursitis
• Polymyositis
• Popliteus tendinopathy
• Posterior cruciate ligament tear
• Posterolateral corner injury
• Prior knee injury
• Pyarthrosis
• Pyrophosphate arthropathy
• Quadriceps tendon tear
• Quadriceps tendinopathy
• Referred knee pain
• Reiter’s syndrome 
• Rickets
• Seronegative spondyloarthropathy 
• Sinding larsen-johannson disease
• Singh-williams-mcalister syndrome 
• Spondyloepiphyseal dysplasia tarda
• Supracondylar femur fracture
• Synovial chondromatosis
• Synovitis
• Talo-patello-scaphoid osteolysis
• Tar syndrome 
• Torn ligament
• Trochlear dysplasia 
• Upper tibia epiphysis
• Weak ankles 

Causes by Organ System

Cardiovascular	Popliteal artery entrapment , Statins
Chemical/Poisoning	Retinoids
Dental	No underlying causes
Dermatologic	Dermatomyositis, Erythema nodosum , Gout
Drug Side Effect	Anthrax vaccination, Fluoroquinolones, Statins, Systemic glucocorticoids, Tetanus vaccination
Ear Nose Throat	Sjögren's syndrome
Endocrine	Primary hyperparathyroidism, Thyroid disease
Environmental	No underlying causes
Gastroenterologic	Hemochromatosis, Pancreas conditions
Genetic	Fairbank disease
Hematologic	Acute leukemia, Bleeding disorders, Hemochromatosis, Hemoglobinopathies, Hemophilia, Leukemia, Popliteal artery aneurysm
Iatrogenic	Clutton's joints, Popliteal artery entrapment , Tetanus vaccination
Infectious Disease	Baker's cyst, Congenital syphilis, Disseminated gonococcal infection, Gonococcal pyarthrosis, Knee bacterial infection, Knee cyst, Knee infection, Neisseria gonorrhoeae, Pyarthrosis, Pyogenic infection, Syphilis, Viral infection, Yersiniosis
Musculoskeletal/Orthopedic	Anterior cruciate ligament tear, Articular cartilage injury, Baker's cyst, Bone contusion, Bone tumors, Brodie knee , Bursitis, Chondromalacia patella, Crystal arthropathy, Degenerative medial meniscal tear , Dislocated knee, Dislocated patella, Epiphyseal dysplasia, Fairbank disease, Fallen arches , Femoral condyle fracture, Fibular head or neck fracture, Fractured patella, Fractured tibial plateau, Gait problems, Hemarthrosis, Hip conditions , Hip dislocation, Hip injury , Hip replacement , Hoffa disease, Housemaid's knee, Howship-romberg sign, Hypertrophic pulmonary osteoarthropathy periostitis, Hypophosphatemic rickets, Iliotibial band syndrome, Intermittent hydrarthrosis, Intra-articular fracture, Jaffe-lichtenstein-sutro syndrome , Johansson-sinding-larsen syndrome, Joint injury , Juvenile chronic arthritis, Juvenile paget's disease , Knee arthritis, Knee bacterial infection, Knee bursitis, Knee conditions, Knee cyst, Knee dislocation, Knee fracture, Knee infection, Knee inflammation, Knee injury , Knee overuse, Knee sprain , Knee strain, Knee tendinitis , Knee tumor, Knock knees, Lateral knee pain , Malignant bone tumor, Medial ligament injury, Medial ligament tear, Meniscal pathology, Meniscus injury , Meniscus tear, Neisseria gonorrhoeae, Neuropathic knee joint, Osgood-schlatter disease, Osteoarthritis, Osteochondritis dissecans, Osteochondrosis, Paget's disease, Patella dislocation or significant subluxation, Patella fracture, Patella stress fracture, Patella subluxation, Patella tendon tear, Patellar tendinitis, Patellar tendinopathy, Patellofemoral pain, Pellegrini-stieda syndrome, Pes anserine bursitis, Polymyositis, Popliteus tendinopathy, Posterior cruciate ligament tear, Posterolateral corner injury, Prior knee injury, Pyarthrosis, Pyrophosphate arthropathy, Quadriceps tendon tear, Quadriceps tendinopathy, Referred knee pain, Reiter’s syndrome , Rickets, Seronegative spondyloarthropathy , Sinding larsen-johannson disease, Singh-williams-mcalister syndrome , Spondyloepiphyseal dysplasia tarda, Supracondylar femur fracture, Synovial chondromatosis, Synovitis, Talo-patello-scaphoid osteolysis, Tar syndrome , Torn ligament, Trochlear dysplasia , Upper tibia epiphysis , Weak ankles
Neurologic	Neuropathic knee joint, Popliteal artery aneurysm, Saphenous nerve entrapment , Sciatica
Nutritional/Metabolic	Scurvy
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute leukemia, Bone tumors, Knee tumor, Leukemia, Lipoma arborescens, Lyme disease - knee arthritis, Malignant bone tumor, Synovial chondromatosis, Synovioma
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Sarcoidosis
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	Ankylosing spondylitis , Arthritis , Bursitis, Crystal arthropathy, Dermatomyositis, Erythema nodosum , Gout , Gram's syndrome , Hoffa disease, Hypertrophic pulmonary osteoarthropathy periostitis, Hypophosphatemic rickets, Iliotibial band syndrome, Intermittent hydrarthrosis, Juvenile rheumatoid arthritis, Knee arthritis, Knee bursitis, Knee inflammation, Knee tendinitis , Knock knees, Lipoarthritis, Lyme disease - knee arthritis, Osgood-schlatter disease, Osteoarthritis, Osteochondritis dissecans, Osteochondrosis, Paget's disease, Patellar tendinopathy, Pes anserine bursitis, Pigmented villonodular synovitis, Plica syndrome, Polymyositis, Popliteal cyst, Popliteus tendinopathy, Pyrophosphate arthropathy, Reiter’s syndrome , Rheumatoid arthritis, Rickets, Sarcoidosis, Sciatica, Septic arthritis, Seronegative spondyloarthropathy , Spondyloepiphyseal dysplasia tarda, Still's disease, Supracondylar femur fracture, Synovial plica syndrome, Synovitis, Systemic lupus erythematosus, Systemic sclerosis, Tar syndrome
Sexual	Congenital syphilis, Syphilis
Trauma	Articular cartilage injury, Chondromalacia patella, Cruciate injury, Degenerative medial meniscal tear , Dislocated knee, Dislocated patella, Fallen arches , Femoral condyle fracture, Fibular head or neck fracture, Fractured patella, Fractured tibial plateau, Gait problems, Hip dislocation, Hip injury , Hip replacement , Howship-romberg sign, Intra-articular fracture, Jaffe-lichtenstein-sutro syndrome , Johansson-sinding-larsen syndrome, Joint injury , Juvenile chronic arthritis, Juvenile paget's disease , Knee dislocation, Knee fracture, Knee injury , Knee overuse, Knee sprain , Knee strain, Lateral knee pain , Medial ligament injury, Medial ligament tear, Meniscal pathology, Meniscus injury , Meniscus tear, Patella dislocation or significant subluxation, Patella fracture, Patella stress fracture, Patella subluxation, Patella tendon tear, Patellar tendinitis, Patellofemoral pain, Posterior cruciate ligament tear, Posterolateral corner injury, Prior knee injury, Quadriceps tendon tear, Quadriceps tendinopathy, Referred knee pain, Synovial plica syndrome, Torn ligament, Trauma, Trochlear dysplasia , Upper tibia epiphysis , Weak ankles
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

• Acute leukemia
• Ankylosing spondylitis
• Anterior cruciate ligament tear
• Anthrax vaccination
• Arthritis 
• Articular cartilage injury
• Baker cyst of knee
• Baker's cyst
• Bleeding disorders
• Bone contusion
• Bone tumors
• Brodie knee
• Bursitis
• Chondromalacia patella
• Clutton's joints
• Congenital syphilis
• Cruciate injury
• Crystal arthropathy
• Degenerative medial meniscal tear 
• Dermatomyositis
• Dislocated knee
• Dislocated patella
• Disseminated gonococcal infection
• Epiphyseal dysplasia
• Erythema nodosum
• Fairbank disease 
• Fallen arches
• Femoral condyle fracture
• Fibular head fracture
• Fluoroquinolones
• Fractured patella
• Fractured tibial plateau
• Gait problems
• Gonococcal pyarthrosis
• Gout
• Gram's syndrome 
• Hemarthrosis
• Hemochromatosis
• Hemoglobinopathies
• Hemophilia
• Hip conditions 
• Hip dislocation 
• Hip injury
• Hip replacement 
• Hoffa disease
• Housemaid's knee
• Howship-romberg sign
• Hypertrophic pulmonary osteoarthropathy periostitis
• Hypophosphatemic rickets
• Iliotibial band syndrome
• Inflammatory arthritis
• Intermittent hydrarthrosis
• Intra-articular fracture
• Jaffe-lichtenstein-sutro syndrome
• Johansson-sinding-larsen syndrome
• Joint injury
• Juvenile chronic arthritis
• Juvenile paget's disease
• Juvenile rheumatoid arthritis
• Knee arthritis
• Knee bacterial infection
• Knee bursitis
• Knee conditions
• Knee cyst
• Knee dislocation
• Knee fracture
• Knee infection
• Knee inflammation
• Knee injury 
• Knee overuse
• Knee sprain 
• Knee strain
• Knee tendinitis
• Knee tumor
• Knock knees
• Lateral knee pain 
• Leukemia
• Lipoarthritis
• Lipoma arborescens
• Lyme disease 
• Malignant bone tumor
• Medial ligament injury
• Medial collateral ligament tear
• Meniscal pathology
• Meniscus injury 
• Meniscus tear
• Neisseria gonorrhoeae
• Neuropathic knee joint
• Osgood-schlatter disease
• Osteoarthritis
• Osteochondirits
• Osteochondritis dissecans
• Osteochondrosis 
• Paget's disease
• Pancreas conditions
• Patella dislocation
• Patella fracture
• Patella stress fracture
• Patella subluxation
• Patella tendon tear
• Patellar tendinitis
• Patellar tendinopathy
• Patellofemoral pain
• Pellegrini-stieda syndrome
• Pes anserine bursitis
• Pigmented villonodular synovitis
• Plica syndrome
• Polymyositis
• Popliteal artery aneurysm
• Popliteal artery entrapment 
• Popliteal cyst
• Popliteus tendinopathy
• Posterior cruciate ligament tear
• Posterolateral corner injury
• Primary hyperparathyroidism
• Prior knee injury
• Pyarthrosis
• Pyogenic infection
• Pyrophosphate arthropathy
• Quadriceps tendon tear
• Quadriceps tendinopathy
• Referred knee pain
• Reiter’s syndrome
• Retinoids
• Rheumatoid arthritis
• Rickets
• Saphenous nerve entrapment 
• Sarcoidosis
• Sciatica
• Scurvy
• Septic arthritis
• Seronegative spondyloarthropathy 
• Sinding larsen-johannson disease
• Singh-williams-mcalister
• Sjögren's syndrome
• Spondyloepiphyseal dysplasia tarda
• Statins
• Still's disease
• Supracondylar femur fracture
• Synovial chondromatosis
• Synovial plica syndrome
• Synovioma
• Synovitis
• Syphilis
• Systemic glucocorticoids
• Systemic lupus erythematosus
• Systemic sclerosis
• Talo-patello-scaphoid osteolysis
• Tar syndrome 
• Tetanus vaccination
• Thyroid disease
• Torn ligament
• Trauma
• Trochlear dysplasia 
• Upper tibia epiphysis and apophysis
• Viral infection
• Weak ankles 
• Yersiniosis