Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

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	Knuckle pads;
ICD-10	M72.1
ICD-9	728.79
OMIM	149100
DiseasesDB	30724
eMedicine	article/1074379

Knuckle pads (also known as "Heloderma", meaning similar to the skin of the Gila monster lizard for which it is named) are circumscribed, keratotic, fibrous growths over the dorsa of the interphalangeal joints.^[1] Knuckle pads are well-defined, round, plaque-like, fibrous thickening that may develop at any age, and grow to be 10 to 15mm in diameter in the course of a few weeks or months, then persist permanently.^[2]^:604 Knuckle pads are sometimes associated with Dupuytren's contracture and camptodactyly^[2]^:604, and histologically, the lesions are fibromas.^[2]^:605

Diagnosis

Physical Examination

Skin

Hand

Knuckle Pads. Adapted from Dermatology Atlas.^[3]
Knuckle Pads. Adapted from Dermatology Atlas.^[3]
Knuckle Pads. Adapted from Dermatology Atlas.^[3]
Knuckle Pads. Adapted from Dermatology Atlas.^[3]

Notes

↑ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). Page 990. McGraw-Hill. ISBN 0-07-138076-0.
↑ ^2.0 ^2.1 ^2.2 James, William; Berger, Julia Meakin, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
↑ ^3.0 ^3.1 ^3.2 ^3.3 "Dermatology Atlas".

References

Guberman D, et al.: Kunckle pads-a forgotten skin condition: report of a case and review of the literature. Cutis 1996;57:241.
Ly Y, et al.: A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads. Am J Med Genet 2003;120A:345.
Peterson CM, et al.: Knuckle pads: does knuckle cracking play an etiologic role? Pediatr Dermatol 2000;17:450.

Template:Dermal-growth-stub Template:Soft tissue disorders

[Fitz2-1] Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). Page 990. McGraw-Hill. ISBN 0-07-138076-0.

[Andrews-2] 2.0 ^2.1 ^2.2 James, William; Berger, Julia Meakin, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.

[Dermatology_Atlas-3] 3.0 ^3.1 ^3.2 ^3.3 "Dermatology Atlas".

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Knuckle pads