LCN1

Lipocalin 1 (tear prealbumin)
File:PBB Protein LCN1 image.jpg PDB rendering based on 1xki.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1xki​
Identifiers
Symbols	LCN1 ; TP; MGC71975; PMFA; VEGP
External IDs	Template:OMIM5 HomoloGene: 48099
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Lipocalin 1 (tear prealbumin), also known as LCN1, is a human gene.

The protein encoded by this gene belongs to the lipocalin family. Lipocalins are a group of extracellular proteins that are able to bind lipophiles by enclosure within their structures to minimize solvent contact. This protein may bind hydrophobic ligands and inhibit cysteine proteinases. It may also play a role in taste reception.

Further reading

• Glasgow BJ, Abduragimov AR, Gasymov OK, Yusifov TN (2003). "Tear lipocalin: structure, function and molecular mechanisms of action". Adv. Exp. Med. Biol. 506 (Pt A): 555–65. PMID 12613960.CS1 maint: Multiple names: authors list (link)
• Redl B, Holzfeind P, Lottspeich F (1992). "cDNA cloning and sequencing reveals human tear prealbumin to be a member of the lipophilic-ligand carrier protein superfamily". J. Biol. Chem. 267 (28): 20282–7. PMID 1400345.CS1 maint: Multiple names: authors list (link)
• Lassagne H, Nguyen VC, Mattei MG, Gachon AM (1995). "Assignment of LCN1 to human chromosome 9 is confirmed". Cytogenet. Cell Genet. 71 (1): 104. PMID 7606920.CS1 maint: Multiple names: authors list (link)
• Bläker M, Kock K, Ahlers C; et al. (1993). "Molecular cloning of human von Ebner's gland protein, a member of the lipocalin superfamily highly expressed in lingual salivary glands". Biochim. Biophys. Acta. 1172 (1–2): 131–7. PMID 7679926.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holzfeind P, Redl B (1994). "Structural organization of the gene encoding the human lipocalin tear prealbumin and synthesis of the recombinant protein in Escherichia coli". Gene. 139 (2): 177–83. PMID 8112601.
• Lassagne H, Ressot C, Mattei MG, Gachon AM (1994). "Assignment of the human tear lipocalin gene (LCN1) to 9q34 by in situ hybridization". Genomics. 18 (1): 160–1. doi:10.1006/geno.1993.1444. PMID 8276406.CS1 maint: Multiple names: authors list (link)
• Lassagne H, Gachon AM (1993). "Cloning of a human lacrimal lipocalin secreted in tears". Exp. Eye Res. 56 (5): 605–9. PMID 8500570.
• Holzfeind P, Merschak P, Rogatsch H; et al. (1996). "Expression of the gene for tear lipocalin/von Ebner's gland protein in human prostate". FEBS Lett. 395 (2–3): 95–8. PMID 8898072.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van't Hof W, Blankenvoorde MF, Veerman EC, Amerongen AV (1997). "The salivary lipocalin von Ebner's gland protein is a cysteine proteinase inhibitor". J. Biol. Chem. 272 (3): 1837–41. PMID 8999869.CS1 maint: Multiple names: authors list (link)
• Redl B, Wojnar P, Ellemunter H, Feichtinger H (1998). "Identification of a lipocalin in mucosal glands of the human tracheobronchial tree and its enhanced secretion in cystic fibrosis". Lab. Invest. 78 (9): 1121–9. PMID 9759656.CS1 maint: Multiple names: authors list (link)
• Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ (1999). "Interaction of tear lipocalin with lysozyme and lactoferrin". Biochem. Biophys. Res. Commun. 265 (2): 322–5. doi:10.1006/bbrc.1999.1668. PMID 10558865.CS1 maint: Multiple names: authors list (link)
• Wojnar P, Lechner M, Merschak P, Redl B (2001). "Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display". J. Biol. Chem. 276 (23): 20206–12. doi:10.1074/jbc.M101762200. PMID 11287427.CS1 maint: Multiple names: authors list (link)
• Wojnar P, van't Hof W, Merschak P; et al. (2002). "The N-terminal part of recombinant human tear lipocalin/von Ebner's gland protein confers cysteine proteinase inhibition depending on the presence of the entire cystatin-like sequence motifs". Biol. Chem. 382 (10): 1515–20. PMID 11727836.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wojnar P, Dirnhofer S, Ladurner P; et al. (2002). "Human lipocalin-1, a physiological scavenger of lipophilic compounds, is produced by corticotrophs of the pituitary gland". J. Histochem. Cytochem. 50 (3): 433–5. PMID 11850445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wojnar P, Lechner M, Redl B (2003). "Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells". J. Biol. Chem. 278 (18): 16209–15. doi:10.1074/jbc.M210922200. PMID 12591932.CS1 maint: Multiple names: authors list (link)
• Glasgow BJ, Abduragimov AR, Gassymov OK; et al. (2003). "Vitamin E associated with the lipocalin fraction of human tears". Adv. Exp. Med. Biol. 506 (Pt A): 567–72. PMID 12613961.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tiffany JM, Nagyová B (2003). "The role of lipocalin in determining the physical properties of tears". Adv. Exp. Med. Biol. 506 (Pt A): 581–5. PMID 12613963.
• Gasymov OK, Abduragimov AR, Yusifov TN, Glasgow BJ (2004). "Interstrand loops CD and EF act as pH-dependent gates to regulate fatty acid ligand binding in tear lipocalin". Biochemistry. 43 (40): 12894–904. doi:10.1021/bi049076o. PMID 15461462.CS1 maint: Multiple names: authors list (link)